Adolescent MDMA exposure diminishes the physiological, behavioral and neurotoxic consequences of a subsequent methamphetamine binge
Joint Authors
Henderson, Christina S.
Piper, Brian J.
Meyer, Jerrold S.
Source
Journal of Drug and Alcohol Research
Issue
Vol. 3, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Previous research showed that repeated adolescent ±3,4- methylenedioxymethamphetamine (MDMA) treatments diminished the temperature dysregulation, hypoactivity/“hangover” effect, and serotonin transporter reductions caused by a subsequent MDMA binge.
This study evaluated whether MDMA would confer crosstolerance against a methamphetamine (METH) binge.
Rats received MDMA (10mg/kg × 2) every fifth day from postnatal day (PD) 35 to PD 60 followed by a low or high METH binge (4 or 8mg/kg×4) on PD 67.
Adolescent MDMA preexposure diminished, but did not prevent, the METH-induced increase in core body temperature.
Adolescent MDMA exposure conferred resistance to the METHinduced hypoactivity in rearing behavior on PD 68.
The high-dose METH binge caused reductions in [3H]citalopram binding to the serotonin transporter in the frontal cortex, parietal cortex, and hippocampus which were attenuated by adolescent MDMA.
Similarly, adolescent MDMA blunted the METH binge-induced decrease in striatal [3H]WIN35,428 binding to the dopamine transporter.
Together, these findings are supportive of a preconditioning effect between the two different substituted amphetamines
American Psychological Association (APA)
Henderson, Christina S.& Piper, Brian J.& Meyer, Jerrold S.. 2014. Adolescent MDMA exposure diminishes the physiological, behavioral and neurotoxic consequences of a subsequent methamphetamine binge. Journal of Drug and Alcohol Research،Vol. 3, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-686132
Modern Language Association (MLA)
Henderson, Christina S.…[et al.]. Adolescent MDMA exposure diminishes the physiological, behavioral and neurotoxic consequences of a subsequent methamphetamine binge. Journal of Drug and Alcohol Research Vol. 3 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-686132
American Medical Association (AMA)
Henderson, Christina S.& Piper, Brian J.& Meyer, Jerrold S.. Adolescent MDMA exposure diminishes the physiological, behavioral and neurotoxic consequences of a subsequent methamphetamine binge. Journal of Drug and Alcohol Research. 2014. Vol. 3, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-686132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 8-10
Record ID
BIM-686132