The relationship between Prostate Specific Antigen (PSA)‎ and oxidative stress in Iraqi women with Polycystic Ovary Syndrome (PCOS)‎

Abstract EN

PCOS is one of the commonest endocrine disorders among the women during their reproductive age .The world-wide prevalence of the disease ranges between (5-10 %).

Those patients were classified in this study into three classes according to Rotterdam criteria which states that PCOS is defined as at least two of three of the following criteria:Obigomenorhea or anovulation, Biochemical signs of increased androgen levels (such as hirsuitism), and Detection of polycystic ovary (Ten or more cysts of 2-10 mm in diameter and in the absence of other endocrine disturbances).

This study included 90 women with PCOS divided into three groups , infertile , hirsute , and combined (both infertile and hirsute) thirty patients of each group, with forty women apparently healthy as a control group.

The measurement of Prostate Specific Antigen (PSA) has been done by using cobas e 411 analyzer.

The oxidative stress has been determined depending on Malondialdehyde (MDA) as a biomarker by spectrophotometric method, the concentrations of total testosterone and sex hormones (LH, FSH) were measured by using ELFA technique.

Total Antioxidant Capacity (TAC), Super Oxide Dismutase (SOD1), Dehydroepiandrosterone (DHEA) concentrations have been measured by using ELISA technique.

The results of BMI showed that highly significant differences between all patient groups compared with control group.

The results revealed a significant differences in levels of (PSA, MDA, TAC, SOD1, Testosterone and LH/FSH Ratio) (P < 0.05, P < 0.01) in all patient groups in comparison with control.

The results demonstrated negative correlation between PSA and MDA in all patient groups, as well as positive correlation between PSA and both of testosterone and LH/FSH Ratio.

From the above results and their correlations we can conclude that PSA considered to be a valuable biomarker for Androgens activity in PCOS patients.

The results also showed that no significant changes in DHEA level this indicates that no contribution of the pituitary-adrenal axis in these changes.