Association ghrelin level with insulin resistance in type 2 diabetes mellitus obese patients

Abstract EN

The aim of this study was to investigate the relationship between serum ghrelin concentration with markers of insulin resistance and obesity in type 2 diabetes, Evaluation of the possible association of the obesity in type 2 diabetes and gene polymorphism.

The results show that the Levels of ghrelin (mean ± S.E) ghrelin was significantly lower in obese type 2 diabetes compared to control group (p< 0.0001) and Levels of ghrelin did not differ between the 49 men and the 59 women.

smoking history was significantly.

ghrelin showed significant negative correlation with BMI ( r = -0.62), Waist/Hip ratio(r = -0.68), SBP (r = -0.53) and DBP( r = -0.43).A significant negative correlation between Ghrelin level and FBG (r = -0.55), HbA1c (r = -0.60), Insulin (r = -0.44) andinsulin resistance index (HOMAIR HOMA-IR(r = -0.46).

There was an inverse correlation between Ghrelin level and cholesterol(r = -0.15), triglycerides(r =-0.38) and VLDL(r = -0.38) respectively, while there is no significant correlation with LDL.

As well as there weresignificant positive correlation between Ghrelin level and HDL.

A significant negative correlation between Ghrelin level and Syctolic bloodpressure and diastolic blood pressure (r = -0.53 andr =-0.43) was observed in the obese type 2 diabetes groups.