Assessment of apoB and apoA-i serum levels associated with Acute Coronary Syndrome (ACS)‎ in Babylon Province

Abstract EN

Acute coronary syndromes (ACS), is a term that encompasses both unstable angina and myocardial infarction (MI) with or without ST-segment elevation.It is a life-threatening disorder that remain a source of high morbidity and mortality despite advances in treatment.

Risk assessment done by using risk factors and risk markers.

In the present study assessment of apolipoprotein B (apoB) and apolipoprotein A-I (apoA-I) done to recognize their roles as risk biomarkers.Acase control study enrolled 160 subjects; 80 patients diagnosed as ACS patients by expert physicians and 80 controls (non-ACS) subjects.

Serum levels of apoB and apoA-I was measured by using ELISA technique.

The results were expressed as qi-square categorical statistics.

A P value of < 0.05 was considered to be statistically significant.

A concentration of apoB >1.3g / L in female and >1.5g / L in male appeared to be eleven times risky for ACS than lower levels (OR = 11.2).ApoA-I showed non-significant variation between patients and controls (p>0.05).

Subjects having apoB / A-I ratio between (0.6-o.79) as a female and (0.7-0.89) as a male are two times risky to get ACS than controls (OR = 2.3).Concluded that apoB is a strong predictor of ACS, abnormal low apoA-I serun level does not contribute to the risk stratification of ACS in the presence of high apoB serum level, and the apo-ratio is the strongest of all lipid-related variables and is thus the best summarizing risk variable.