Role of GIRK channels in addictive substance effects
Joint Authors
Sugaya, Nagisa
Kobayashi, Toru
Ikeda, Kazutaka
Source
Journal of Drug and Alcohol Research
Issue
Vol. 2, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Publication Date
2013-12-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
G-protein-activated inwardly rectifying potassium (GIRK) channels are widely expressed in the central nervous system, including brain regions related to reward, and play an important role in mediating the signal transduction pathways of various addictive substances.
Studies of GIRK knockout mice have suggested the involvement of GIRK channels in the mechanisms that underlie the effects of addictive substances.
Human studies have shown that differences in the genetic sequence of one of the four GIRK channel subunits, GIRK2, are associated with analgesic requirements in patients who undergo major open abdominal surgery.
Animal and human studies also showed the possible therapeutic effects of GIRK channel inhibitors in the treatment of methamphetamine dependence and alcoholism.
These findings suggest that GIRK channels may be a key molecular target in the reward system for the treatment of addiction.
American Psychological Association (APA)
Sugaya, Nagisa& Kobayashi, Toru& Ikeda, Kazutaka. 2013. Role of GIRK channels in addictive substance effects. Journal of Drug and Alcohol Research،Vol. 2, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-687210
Modern Language Association (MLA)
Sugaya, Nagisa…[et al.]. Role of GIRK channels in addictive substance effects. Journal of Drug and Alcohol Research Vol. 2 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-687210
American Medical Association (AMA)
Sugaya, Nagisa& Kobayashi, Toru& Ikeda, Kazutaka. Role of GIRK channels in addictive substance effects. Journal of Drug and Alcohol Research. 2013. Vol. 2, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-687210
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 8-11
Record ID
BIM-687210