PPAR agonist rescue of ethanol-impaired brain insulin signaling : cerebellar slice culture model
Joint Authors
Tong, Ming
Le, Tran
Nguyen, VanAnh
Monte, Suzanne M. de la
Source
Journal of Drug and Alcohol Research
Issue
Vol. 2, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Publication Date
2013-12-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cerebellar abnormalities in fetal alcohol spectrum disorder (FASD) have been linked to brain insulin resistance and oxidative stress.
Peroxisome proliferator-activated receptor (PPAR) agonists, which have insulin sensitizer and antioxidant effects, could potentially be used to treat neurodevelopmental abnormalities in FASD.
Slice cultures generated with cerebella from control or ethanol-exposed rat pups were treated with vehicle, or a PPAR-α, PPAR-δ , or PPAR-γ agonist to examine effects on cytotoxicity, histopathology, insulin signaling, and neuronal/glial protein expression.
PPAR agonists reduced ethanol-mediated cytotoxicity; restored cerebellar architecture; increased expression or activation of insulin/IGF- 1 receptors, IRS-1, Akt, and PRAS40; and inhibited GSK-3β.
PPAR agonists increased the expression of Hu, myelin-associated glycoprotein-1, and choline acetyltransferase, and decreased the oxidative stress in ethanol-exposed cultures.
The PPAR-δ and PPAR-γ agonists weremore effective than the PPAR-α agonist in abrogating the adverse effects of ethanol.
Therefore, early treatment with PPAR-δ or PPAR-γ agonists may help prevent long-term consequences of FASD.
American Psychological Association (APA)
Le, Tran& Tong, Ming& Nguyen, VanAnh& Monte, Suzanne M. de la. 2013. PPAR agonist rescue of ethanol-impaired brain insulin signaling : cerebellar slice culture model. Journal of Drug and Alcohol Research،Vol. 2, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-687214
Modern Language Association (MLA)
Le, Tran…[et al.]. PPAR agonist rescue of ethanol-impaired brain insulin signaling : cerebellar slice culture model. Journal of Drug and Alcohol Research Vol. 2 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-687214
American Medical Association (AMA)
Le, Tran& Tong, Ming& Nguyen, VanAnh& Monte, Suzanne M. de la. PPAR agonist rescue of ethanol-impaired brain insulin signaling : cerebellar slice culture model. Journal of Drug and Alcohol Research. 2013. Vol. 2, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-687214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-9
Record ID
BIM-687214