The evaluation of sevoflurane-induced apoptotic neurodegeneration with microPET using [18F]-DFNSH in the developing rat brain
Joint Authors
Liu, Shuliang
Newport, Glenn D.
Wang, Cheng
Patterson, Tucker A.
William Slikker, Jr.
Ali, Sayyid F.
Apana, Scott M.
Paule, Merle G.
Berridge, Marc S.
Zhang, Xuan
Source
Journal of Drug and Alcohol Research
Issue
Vol. 2, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Publication Date
2013-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
General anesthetic-induced apoptotic neurodegeneration confirmed in animal models caused substantial concerns over the safety of pediatric patients undergoing general anesthesia.
Therefore, studies in search of translational molecular probes for labeling apoptotic neurons are imperative.
The purpose of the current study is to examine the utility of [18F]-DFNSH as an apoptosis probe for positron emission tomography (PET) in evaluating sevofluraneinduced neuronal apoptosis in the developing rat brain.
Neonatal rats were exposed to 2.5% sevoflurane for 3, 6, or 9 h on postnatal day (PND) 7.
MicroPET scans using [18F]-DFNSH as radiotracer were performed in weeks 1, 3, or 8 after sevoflurane exposure, respectively.
In week 1 or 3 after sevoflurane exposure, standard uptake values (SUVs) in frontal cortex in the 9-h-exposed rats, but not in 3- or 6-h-exposed rats, are significantly higher than those of the controls, suggesting increased uptake and retention of [18F]-DFNSH.
Interestingly, the uptake of this tracer was attenuated in 9-h-exposed rats when co-administered with L-carnitine.
Collectively, the results suggest that [18F]-DFNSH-PET studies can help define the temporal course of sevoflurane-induced apoptosis in the developing rat brain.
American Psychological Association (APA)
Liu, Shuliang& Paule, Merle G.& Zhang, Xuan& Newport, Glenn D.& Apana, Scott M.& Berridge, Marc S.…[et al.]. 2013. The evaluation of sevoflurane-induced apoptotic neurodegeneration with microPET using [18F]-DFNSH in the developing rat brain. Journal of Drug and Alcohol Research،Vol. 2, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-687300
Modern Language Association (MLA)
Liu, Shuliang…[et al.]. The evaluation of sevoflurane-induced apoptotic neurodegeneration with microPET using [18F]-DFNSH in the developing rat brain. Journal of Drug and Alcohol Research Vol. 2 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-687300
American Medical Association (AMA)
Liu, Shuliang& Paule, Merle G.& Zhang, Xuan& Newport, Glenn D.& Apana, Scott M.& Berridge, Marc S.…[et al.]. The evaluation of sevoflurane-induced apoptotic neurodegeneration with microPET using [18F]-DFNSH in the developing rat brain. Journal of Drug and Alcohol Research. 2013. Vol. 2, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-687300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6-7
Record ID
BIM-687300