Ethanol-induced conditioning place avoidance impairs acute stimulant locomotor effect of cocaine
Joint Authors
Varela, Patricia
Tesone Coelho, Carolina
Escosteguy Neto, Joao C.
Mello, Luiz E.
Santos-Junior, Jair G.
Source
Journal of Drug and Alcohol Research
Issue
Vol. 1, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
According to the rewarding properties of ethanol in the place conditioning protocol, outbred Swiss mice may be distinguished in three subgroups : (i) place preference (EtOH Cpp); (ii) place avoidance (EtOH Cpa); (iii) indifference (EtOH Ind).
Here we evaluated whether the anxiety-like state and cocaine stimulant locomotor effect are altered in these different phenotypes.
No differences were observed in the anxiety-like state before and after conditioning among the different groups.
However, animals were generally more anxious-like after the conditioning protocol.
EtOH Cpp and EtOH Ind groups (but not EtOH Cpa) increased their locomotor activity after cocaine injection, when compared to Control.
We verified an individual variability in outbred Swiss mice regarding the appetitive effects of ethanol.
Anxiety-like state apparently is not involved in the expression of these phenotypes.
Interestingly, non-aversive hedonic value of ethanol pairing is essential to maintain cocaine-induced hyperlocomotion, since mice aversion to ethanol conditioning impairs acute cocaine-induced stimulating effects.
American Psychological Association (APA)
Tesone Coelho, Carolina& Varela, Patricia& Escosteguy Neto, Joao C.& Mello, Luiz E.& Santos-Junior, Jair G.. 2012. Ethanol-induced conditioning place avoidance impairs acute stimulant locomotor effect of cocaine. Journal of Drug and Alcohol Research،Vol. 1, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-687366
Modern Language Association (MLA)
Tesone Coelho, Carolina…[et al.]. Ethanol-induced conditioning place avoidance impairs acute stimulant locomotor effect of cocaine. Journal of Drug and Alcohol Research Vol. 1 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-687366
American Medical Association (AMA)
Tesone Coelho, Carolina& Varela, Patricia& Escosteguy Neto, Joao C.& Mello, Luiz E.& Santos-Junior, Jair G.. Ethanol-induced conditioning place avoidance impairs acute stimulant locomotor effect of cocaine. Journal of Drug and Alcohol Research. 2012. Vol. 1, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-687366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 9-10
Record ID
BIM-687366