Profile of MDMA self-administration from a large cohort of rats : MDMA develops a profile of dependence with extended testing
Joint Authors
Schenk, Susan
Colussi Mas, Joyce
Do, Jennifer
Bird, Judith
Source
Journal of Drug and Alcohol Research
Issue
Vol. 1, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The present study provides a profile of acquisition and maintenance of self-administration of + / -3, 4- methylenedioxymethamphetamine (MDMA) obtained from a large cohort of rats tested during a 2 year period.
Of the 128 rats, 49 % self-administered 1.0 mg/kg/infusion MDMA to an initial criterion within a 25 day cut-off period.
The number of test sessions required to meet this initial criterion was normally distributed around an average of 15.9 days and responding increased in a compensatory manner when the dose was decreased.
In a subgroup of rats that self-administered MDMA for an additional 14 days intake increased from 8.5 to 15.25 mg/kg/day.
Thus, under these conditions, MDMA is a reliable reinforcer for about half of a large sample of rats, responding is dose-dependent and acquisition of self-administration for these sensitive rats requires more test sessions than is typically used for studies examining self-administration of other drugs of abuse.
American Psychological Association (APA)
Schenk, Susan& Colussi Mas, Joyce& Do, Jennifer& Bird, Judith. 2012. Profile of MDMA self-administration from a large cohort of rats : MDMA develops a profile of dependence with extended testing. Journal of Drug and Alcohol Research،Vol. 1, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-687376
Modern Language Association (MLA)
Schenk, Susan…[et al.]. Profile of MDMA self-administration from a large cohort of rats : MDMA develops a profile of dependence with extended testing. Journal of Drug and Alcohol Research Vol. 1 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-687376
American Medical Association (AMA)
Schenk, Susan& Colussi Mas, Joyce& Do, Jennifer& Bird, Judith. Profile of MDMA self-administration from a large cohort of rats : MDMA develops a profile of dependence with extended testing. Journal of Drug and Alcohol Research. 2012. Vol. 1, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-687376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-687376