Assessment of potential neuronal toxicity of inhaled anesthetics in the developing nonhuman primate
Joint Authors
Liu, Shuliang
Zhang, Xuan
Wang, Cheng
Patterson, Tucker A.
William Slikker, Jr.
Ali, Sayyid F.
Paule, Merle G.
Liu, Fang
Source
Journal of Drug and Alcohol Research
Issue
Vol. 1, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Anesthetics have been used for years in pediatric patients without clinical evidence of adverse central nervous system (CNS) sequelae.
In the current study, postnatal day (PND) 5–6 rhesus monkeys were exposed to nitrous oxide (N2O; 70%) alone, isoflurane (ISO; 1.0%) alone, or N2O plus ISO for 8 h.
Six hours after completion of anesthetic administration, neuronal toxicity was examined using histochemical and molecular imaging approaches.
Histochemical data demonstrated that exposure of the developing monkey to the inhaled anesthetic combination for 8 h results in significantly enhanced neuronal cell death in frontal cortex, temporal gyrus, and hippocampus.
Imaging techniques also demonstrated that such anesthetic exposure causes significant neuronal damage in cortical brain regions as indicated by an elevated binding of the specific peripheral benzodiazepine receptor radiotracer [18F]-N- (2-(2-fluoroethoxy)benzyl)-N-(4-phenoxypyridin-3-yl) acetamide ([18F]-FEPPA), a marker of activated microglia or inflammatory responses.
No significant neurotoxic effects were observed in monkeys treated with N2O alone, ISO alone, or in monkeys treated with the anesthetic combination for only 3 h.
These data suggest that prolonged exposures to inhaled anesthetics in the developing rhesus monkey can result in significant neuronal damage.
American Psychological Association (APA)
Liu, Fang& Zhang, Xuan& Patterson, Tucker A.& Liu, Shuliang& Ali, Sayyid F.& Paule, Merle G.…[et al.]. 2012. Assessment of potential neuronal toxicity of inhaled anesthetics in the developing nonhuman primate. Journal of Drug and Alcohol Research،Vol. 1, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-687388
Modern Language Association (MLA)
Liu, Fang…[et al.]. Assessment of potential neuronal toxicity of inhaled anesthetics in the developing nonhuman primate. Journal of Drug and Alcohol Research Vol. 1 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-687388
American Medical Association (AMA)
Liu, Fang& Zhang, Xuan& Patterson, Tucker A.& Liu, Shuliang& Ali, Sayyid F.& Paule, Merle G.…[et al.]. Assessment of potential neuronal toxicity of inhaled anesthetics in the developing nonhuman primate. Journal of Drug and Alcohol Research. 2012. Vol. 1, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-687388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 8-9
Record ID
BIM-687388