Chronic methamphetamine causes differential expression of immediate early genes in the nucleus accumbens and midbrain of rats
Joint Authors
Jayanthi, Subramaniam
McCoy, Michael T.
Ladenheim, Bruce
Cadet, Jean Lud
Garrett, Tiffany
Tulloch, Ingrid
Krasnova, Irina
Beauvais, Genevieve
Hodges, Amber
Davis, Carolyn
Source
Journal of Drug and Alcohol Research
Issue
Vol. 1, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The present study investigated whether chronic methamphetamine (METH) would suppress METHinduced mRNA expression of immediate early genes (IEGs) in the rat brain.
Rats were given METH or saline over two weeks.
After an overnight withdrawal, salineand METH-pretreated rats received an acute saline or METH challenge.
The acute METH challenge increased expression of members of activator protein 1 (AP-1) and Nr4a IEG families in the nucleus accumbens (NAc) and midbrain of saline-pretreated rats.
Chronic METH exposure attenuated the effects of acute METH challenge on AP-1 IEG expression in the NAc.
However, chronic METH failed to attenuate acute METH-induced increases of Nr4a1 and Nr4a3 expression in the NAc.
In contrast to observations in the NAc, chronic METH did not prevent acute METHinduced changes in IEG expression in the midbrain.
These results suggest that these two brain regions that are implicated in neuroplastic effects of illicit substances might be differentially affected by psychostimulants.
American Psychological Association (APA)
Garrett, Tiffany& Tulloch, Ingrid& McCoy, Michael T.& Ladenheim, Bruce& Jayanthi, Subramaniam& Krasnova, Irina…[et al.]. 2012. Chronic methamphetamine causes differential expression of immediate early genes in the nucleus accumbens and midbrain of rats. Journal of Drug and Alcohol Research،Vol. 1, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-687404
Modern Language Association (MLA)
Garrett, Tiffany…[et al.]. Chronic methamphetamine causes differential expression of immediate early genes in the nucleus accumbens and midbrain of rats. Journal of Drug and Alcohol Research Vol. 1 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-687404
American Medical Association (AMA)
Garrett, Tiffany& Tulloch, Ingrid& McCoy, Michael T.& Ladenheim, Bruce& Jayanthi, Subramaniam& Krasnova, Irina…[et al.]. Chronic methamphetamine causes differential expression of immediate early genes in the nucleus accumbens and midbrain of rats. Journal of Drug and Alcohol Research. 2012. Vol. 1, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-687404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6-7
Record ID
BIM-687404