Clinicopathologic spectrum of gastrointestinal stromal tumours : Six Years experience at King Hussein Medical Center

Abstract EN

Objectives : To study the clinicopathologic features of gastrointestinal stromal tumors (GISTs), to identify the frequency of risk categories and to predict prognostic factors for disease outcome.

Methods : This is a retrospective review of gastrointestinal stromal tumor cases that conducted at department of surgery at King Hussein Medical Center between January 2007 to December 2013.

A total of 42 cases of c-KIT (CD117) positive GISTs were included in this study.

Clinical data and histopathological parameters were reviewed.

Categorization of risk groups was done according to the National Institute of Health.

Results : There were 25 males and 17 females.

The mean age of presentation was 56.8 years in males and in 51 years in females.

The most common origin of GISTs was stomach in 61.9% followed by small intestine 19 %, for colon and rectum 4.7 % and 14.4 % in others (pancreas, ovaries).

Abdominal pain was the most common presentation for 42 % of cases studied.

21.4 % of cases were presented with distant metastasis.

Spindle cell morphology was the commonest histopathological pattern observed in (54.7 %).

Risk categorization based on tumor size and cell proliferation as estimated by mitosis revealed that 59.5 % of patients in our clinical settings belonged to high risk group.

Conclusion: Most of the cases in this group of Jordanian patients belonged to high risk group.

Certain clinical and histopathological features including tumor size > 10 cm, mitotic rate ≥ 10 / 50HPF, tumor necrosis, mucosal ulceration and non-gastric site may be predictors for poor outcome in patients suffering from GISTs.