Modulatory effects of date palm (Phoenix dactylifera L.) pits extract against ethinylestradiol induced genotoxic damage in cultured human lymphocytes
Other Title(s)
الفعالية المعتلة لمستخلص نوى التمر ضد عقار Ethinylestradiol الذي يسبب ضررا بالمادة الوراثية للخلايا اللمفاوية البشرية المزروعة
Author
al-Juraisi, Yasir Husayn Zaydan
Source
Issue
Vol. 57, Issue 1C (31 Mar. 2016), pp.576-582, 7 p.
Publisher
University of Baghdad College of Science
Publication Date
2016-03-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
- Physiological effects
- Toxicology
- Organ transplantation
- Plant extracts
- Genetic aspects
- Palms
- Dates(Fruit)
- Tissue culture
- Lymphocytes
- Norethindrone
Abstract EN
Ethinylestradiol is widely used in oral contraceptive formulations and also for the treatment of various sexual and metabolic disorders.
It is not only a genotoxic agent but also a tumor initiating agent.
In the present study, the modulatory effect of aqueous extract of date pits was evaluated against the genotoxic effect induced by ethinylestradiol on human lymphocytes using chromosomal aberrations (CA), blast index (BI), mitotic index (MI), sister chromatid exchanges (SCE) and replication index (RI) as parameters.
The date pits extract was evaluated at 1.075 x 10-4, 2.125 x 10-4, 3.15 x 10-4 and 4.17 x 10-4 g/ml along with 10 μM of ethinylestradiol in culture medium.
The results showed a significant dose-dependent decrease in the frequency of CA and SCE induced by ethinylestradiol.
The results of the present study suggest that the plant extract per se does not have genotoxic potential, but can modulate the genotoxicity of ethinylestradiol in cultured human lymphocytes.
American Psychological Association (APA)
al-Juraisi, Yasir Husayn Zaydan. 2016. Modulatory effects of date palm (Phoenix dactylifera L.) pits extract against ethinylestradiol induced genotoxic damage in cultured human lymphocytes. Iraqi Journal of Science،Vol. 57, no. 1C, pp.576-582.
https://search.emarefa.net/detail/BIM-688539
Modern Language Association (MLA)
al-Juraisi, Yasir Husayn Zaydan. Modulatory effects of date palm (Phoenix dactylifera L.) pits extract against ethinylestradiol induced genotoxic damage in cultured human lymphocytes. Iraqi Journal of Science Vol. 57, no. 1C (2016), pp.576-582.
https://search.emarefa.net/detail/BIM-688539
American Medical Association (AMA)
al-Juraisi, Yasir Husayn Zaydan. Modulatory effects of date palm (Phoenix dactylifera L.) pits extract against ethinylestradiol induced genotoxic damage in cultured human lymphocytes. Iraqi Journal of Science. 2016. Vol. 57, no. 1C, pp.576-582.
https://search.emarefa.net/detail/BIM-688539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 580-582
Record ID
BIM-688539