Role of tc 99m sestamibi in assessment of treatment response to chemotherapy in bone sarcomas

Abstract EN

The aim of this prospective study is to test the value of Tc99m MIBI scanning in assessment of response of bone sarcomas to chemotherapy.

It included 28 patients with primary bone tumors [18 patients with osteosarcoma, 10 patients with Ewing's sarcoma (ES)].

Their age ranged from 8-19 years, 24 males and 4 females.

All patients had pre-chemotherapy assessment with 20 mCi of Tc-99m MDP triple phase bone scan.

Early dynamic and blood pool whole body scan (WBS) imaging at 2-5 min post injection and delayed (3 hours) image were acquired to assess the primary lesion and exclude metastatic spread.

Both early (20 min) and delayed (2 hrs.) WBS images with Tc-99m SestaMIBI were performed before chemotherapy and after 3-4 courses of chemotherapy to assess chemotherapy treatment response.

Imaging was done on dual head gamma camera interfaced with a recent version computer system.

Images were interpreted both qualitatively and quantitatively.

Correlation of Tc99m MIBI scan with tumor percentage necrosis in histo-pathological examination was possible in 19 patients following salvage surgery for the involved limb.

The remaining 9 patients were assessed clinically and radiologically in comparison with Tc-99m MIBI WBS.