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Prognostic significance of E-cadherin expression in gastric cancer
Joint Authors
Hasan, Azzah Adil
Maghribi, Halah K.
al-Sayyid, Khalid
Source
Journal of the Medical Research Institute
Issue
Vol. 27, Issue 4 (31 Dec. 2006), pp.271-278, 8 p.
Publisher
Alexandria University Medical Research Institute
Publication Date
2006-12-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background : E-cadherin plays a key role in intercellular adhesion of epithelial cells.
Aberrant expression of E-cadherin have been implicated in tumor progression and metastasis.
Aim : the expression pattern of E-cadherin in gastric carcinoma, its relationship with tumour clinic pathological parameters and patient survival as well as efficacy of postoperative adjuvant treatment were investigated.
Methods : the expression of E-cadherin was evaluated by immunohistochemistry in 33 formalin fixed paraffin embedded specimens of gastric cancer.
The patients received the planned postoperative adjuvant treatment.
Results : Abnormal expression of E-cadherin demonstrated in 16 out of 33 cases (48.5%) of gastric carcinoma.
Abnormal staining pattern of Cadherin associated significantly with tumour larger than 10 cm, poorly differentiated and diffuse type carcinoma.
Loss of normal E-cadherin expression showed association with poor survival but not statistically significant (P = 0.1).
The overall survival was 66.7% in the first year and was 48.5% in the second year.
Better disease free survival was seen in chemo-radiotherapy treatment as compared to systemic chemotherapy alone (66% v.44%).
Conclusion : these results suggest that the E-cadherin may be a useful marker of differentiation and prognosis in gastric cancer.
The postoperative adjuvant treatment; concurrent chemo radiotherapy has proved to cause promising improvement in disease free survival.
Further studies are warranted to clarify the impact of E-cadherin on prognostic factor of gastric cancer.
American Psychological Association (APA)
Maghribi, Halah K.& Hasan, Azzah Adil& al-Sayyid, Khalid. 2006. Prognostic significance of E-cadherin expression in gastric cancer. Journal of the Medical Research Institute،Vol. 27, no. 4, pp.271-278.
https://search.emarefa.net/detail/BIM-68918
Modern Language Association (MLA)
Maghribi, Halah K.…[et al.]. Prognostic significance of E-cadherin expression in gastric cancer. Journal of the Medical Research Institute Vol. 27, no. 4 (2006), pp.271-278.
https://search.emarefa.net/detail/BIM-68918
American Medical Association (AMA)
Maghribi, Halah K.& Hasan, Azzah Adil& al-Sayyid, Khalid. Prognostic significance of E-cadherin expression in gastric cancer. Journal of the Medical Research Institute. 2006. Vol. 27, no. 4, pp.271-278.
https://search.emarefa.net/detail/BIM-68918
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 276-278
Record ID
BIM-68918