![](/images/graphics-bg.png)
Synthesis and characterization of new ethyl-2- (5-benzoxazol-2-ylamine-1H-tetrazol-1-yl) acetate derivatives
Author
Source
Engineering and Technology Journal
Issue
Vol. 34, Issue 2B (29 Feb. 2016), pp.287-294, 8 p.
Publisher
Publication Date
2016-02-29
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
The present research work describes the synthesis of new heterocyclic compounds.
The 2- Hydrazino benzoxazole pre-prepared was reacted with sodium nitrite and CuCN and afford the 2-cyano amine benzoxazole(1).Compound(1) react with sodium azide and ammonium chloride in DMF afford the 1-H-tetrazole-5-amino benzoxazole(2) ,ethyl chloroacetate react with compound (2) to give ethyl -2-(5-benzoxazol-2-ylamine)-1H-tetrazol-1-yl) acetate compound (3).Treatment (3)with thiourea or urea afforded compounds (4,5),p-bromo phenacyl bromide react with compounds (4,5) afforded (6,7),treatment (3) with hydrazine hydrate to afforded 2-(5- benzoxazol-2-ylamino)1-H-tetrazol-1yl) acetohydrazide compound (8) .
Azomethines (9, 10) were prepared through reaction of compound (8) with aromatic aldehyde, then (9,10) converted to thaizolidinone derivatives (11,12) after treatment with HSCH2COOH .
Reaction of compound (8) with phenyl iso thiocyanate and ethyl chloro acetate afforded compounds (13, 14) respectively.
All compounds were confirmed by their melting point, FT-IR spectrum,1 HNMR spectrum for some them.
American Psychological Association (APA)
Abbud, Nisrin Qays. 2016. Synthesis and characterization of new ethyl-2- (5-benzoxazol-2-ylamine-1H-tetrazol-1-yl) acetate derivatives. Engineering and Technology Journal،Vol. 34, no. 2B, pp.287-294.
https://search.emarefa.net/detail/BIM-689216
Modern Language Association (MLA)
Abbud, Nisrin Qays. Synthesis and characterization of new ethyl-2- (5-benzoxazol-2-ylamine-1H-tetrazol-1-yl) acetate derivatives. Engineering and Technology Journal Vol. 34, no. 2B (2016), pp.287-294.
https://search.emarefa.net/detail/BIM-689216
American Medical Association (AMA)
Abbud, Nisrin Qays. Synthesis and characterization of new ethyl-2- (5-benzoxazol-2-ylamine-1H-tetrazol-1-yl) acetate derivatives. Engineering and Technology Journal. 2016. Vol. 34, no. 2B, pp.287-294.
https://search.emarefa.net/detail/BIM-689216
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 293-294
Record ID
BIM-689216