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Hypothalamic-pituitary dysfunction following external cranial irradiation
Joint Authors
al-Ghandur, Ashraf H.
al-Sayyid, Amr Abd al-Aziz Abd al-Aziz
al-Burdini, Majdi
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 13, Issue 1 (31 Mar. 2001), pp.71-77, 7 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2001-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background : Deficiency of one or more anterior pituitary hormones may follow treatment with external radiation when the hypothalamic-pituitary axis falls in the fields of radiation.
Patients and methods : Twenty eight patients (12 children with a mean age of 6.92 ± 2.78 years and 16 adults with a mean age of 36.56±13.38 years) were included in the study.
The radiation dose received ranged from 28 to 50 Gy in children and 45 to 60 in adults.
Serum concentration of GH was measured with insulin, basal serum estimation of thyroid stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), prolactin (PRL), luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone were estimated before and after irradiation.
Results : Eight patients in the pediatric group (66%) and 2 patients in the adult group had GH deficiency.
Fifty percent of the pediatric group and 6.25% of the adult group had low serum TSH.
Three patients in the pediatric group had ACTH deficiency.
Twenty five percent of the pediatric group and 6.25% of the adult group had low serum LH / FSH.
Four patients in both groups had elevated PRL.
Testosterone level was low in three patients in the pediatric group and one patient in the adult group.
There were significant negative correlation between serum peak GH, ACTH, LH / FSH, testosterone and the dose of irradiation.
Conclusion : Patients exposed to high-dose radiotherapy ( > 35 Gy) to the hypothalamic-pituitary axis, a variety of endocrine abnormalities may occur, including deficiencies of GH, TSH, ACTH and LH/FSH as well as hypersecretion of prolactin.
American Psychological Association (APA)
al-Sayyid, Amr Abd al-Aziz Abd al-Aziz& al-Ghandur, Ashraf H.& al-Burdini, Majdi. 2001. Hypothalamic-pituitary dysfunction following external cranial irradiation. Journal of the Egyptian National Cancer Institute،Vol. 13, no. 1, pp.71-77.
https://search.emarefa.net/detail/BIM-68933
Modern Language Association (MLA)
al-Ghandur, Ashraf H.…[et al.]. Hypothalamic-pituitary dysfunction following external cranial irradiation. Journal of the Egyptian National Cancer Institute Vol. 13, no. 1 (Mar. 2001), pp.71-77.
https://search.emarefa.net/detail/BIM-68933
American Medical Association (AMA)
al-Sayyid, Amr Abd al-Aziz Abd al-Aziz& al-Ghandur, Ashraf H.& al-Burdini, Majdi. Hypothalamic-pituitary dysfunction following external cranial irradiation. Journal of the Egyptian National Cancer Institute. 2001. Vol. 13, no. 1, pp.71-77.
https://search.emarefa.net/detail/BIM-68933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 75-77
Record ID
BIM-68933