Computational analysis for antimicrobial active pyrano [2, 3-d] pyrimidine derivatives on the basis of theoretical and experimental ground

Joint Authors

Bhat, Ajmal R.
Dongre, Rajendra S.
Shalla, Abid H.
Naikoo, Gowhar A.
al-Husayn, Isra

Source

Arab Journal of Basic and Applied Sciences

Issue

Vol. 20, Issue 0 (30 Jun. 2016), pp.19-25, 7 p.

Publisher

University of Bahrain College of Science

Publication Date

2016-06-30

Country of Publication

Bahrain

No. of Pages

7

Main Subjects

Biology

Abstract EN

Annulated pyrano[2,3-d]pyrimidine derivatives were synthesized with methoxy, hydroxyl, nitrile and bromine substituents in its skeleton and correlated by electronic effect of substituents on the magnitude of antimicrobial activity.

The different electron donating and electron withdrawing substituents of the pyrano[2,3-d]pyrimidine derivatives exerted positive influence on its antimicrobial activity against some Gram positive and Gram negative bacteria such as, Bacillus cereus, Staphylococcus aureus, Klebsiella pneumonia, Pseudomonas aureus and Escherichia coli, respectively.

Antibacterial screening revealed that the presence of heteroaryl, cyano and amino groups on pyrano [2,3-d]pyrimidine skeleton increases its penetrating power on bacterial cell wall and becomes more biologically active.

All the pyrano[2,3-d]pyrimidine derivatives were characterized by IR, 1HNMR, 13C NMR and mass spectra.

American Psychological Association (APA)

Bhat, Ajmal R.& Dongre, Rajendra S.& Shalla, Abid H.& Naikoo, Gowhar A.& al-Husayn, Isra. 2016. Computational analysis for antimicrobial active pyrano [2, 3-d] pyrimidine derivatives on the basis of theoretical and experimental ground. Arab Journal of Basic and Applied Sciences،Vol. 20, no. 0, pp.19-25.
https://search.emarefa.net/detail/BIM-689345

Modern Language Association (MLA)

Bhat, Ajmal R.…[et al.]. Computational analysis for antimicrobial active pyrano [2, 3-d] pyrimidine derivatives on the basis of theoretical and experimental ground. Arab Journal of Basic and Applied Sciences Vol. 20 (Jun. 2016), pp.19-25.
https://search.emarefa.net/detail/BIM-689345

American Medical Association (AMA)

Bhat, Ajmal R.& Dongre, Rajendra S.& Shalla, Abid H.& Naikoo, Gowhar A.& al-Husayn, Isra. Computational analysis for antimicrobial active pyrano [2, 3-d] pyrimidine derivatives on the basis of theoretical and experimental ground. Arab Journal of Basic and Applied Sciences. 2016. Vol. 20, no. 0, pp.19-25.
https://search.emarefa.net/detail/BIM-689345

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 24-25

Record ID

BIM-689345