Investigation of role of aspartame on apoptosis process in HeLa cells
Joint Authors
Pandurangan, Muthuraman
Chandrasekaran, Murugesan
Noorzai, Rafi
Enkhtaivan, Gansukh
Kim, Doo Hwan
Source
Saudi Journal of Biological Sciences
Issue
Vol. 23, Issue 4 (31 Jul. 2016), pp.503-506, 4 p.
Publisher
Publication Date
2016-07-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Abstract EN
Aspartame is an artificial sweetener used as an alternate for sugar in several foods and beverages.
The study reports that consumption of aspartame containing product could lead to cancer.
However, the effect of aspartame on apoptosis process in cancer is not yet understood clearly.
HeLa cells were exposed to different concentrations (0.01–0.05 mg / ml) of aspartame for 48 h.
Cytotoxicity of aspartame on cancer cells was determined by SRB assay.
The result indicates no significant changes on cell viability.
Aspartame suppresses apoptosis process in cancer cells by down-regulation of mRNA expression of tumor suppressor gene p53, and pro-apoptotic gene bax.
It up-regulates anti-apoptotic gene bcl-2 mRNA expression.
In addition, Ki 67 and PCNA mRNA, and protein expressions were determined.
Taking all these together, we conclude that aspartame may be a potent substance to slow-down the apoptosis process in HeLa cells.
Further works are ongoing to understand the biochemical and molecular mechanism of aspartame in cancer cells.
American Psychological Association (APA)
Pandurangan, Muthuraman& Enkhtaivan, Gansukh& Chandrasekaran, Murugesan& Noorzai, Rafi& Kim, Doo Hwan. 2016. Investigation of role of aspartame on apoptosis process in HeLa cells. Saudi Journal of Biological Sciences،Vol. 23, no. 4, pp.503-506.
https://search.emarefa.net/detail/BIM-689570
Modern Language Association (MLA)
Enkhtaivan, Gansukh…[et al.]. Investigation of role of aspartame on apoptosis process in HeLa cells. Saudi Journal of Biological Sciences Vol. 23, no. 4 (Jul. 2016), pp.503-506.
https://search.emarefa.net/detail/BIM-689570
American Medical Association (AMA)
Pandurangan, Muthuraman& Enkhtaivan, Gansukh& Chandrasekaran, Murugesan& Noorzai, Rafi& Kim, Doo Hwan. Investigation of role of aspartame on apoptosis process in HeLa cells. Saudi Journal of Biological Sciences. 2016. Vol. 23, no. 4, pp.503-506.
https://search.emarefa.net/detail/BIM-689570
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 506
Record ID
BIM-689570