Evaluation study of patients infected with Chronic Hepatitis C in Iraq
Joint Authors
Muhsin, Layth H.
al-Akayshi, Ragad J.
Mhawis, Ali A.
Source
al-Kindy College Medical Journal
Issue
Vol. 11, Issue 2 (31 Dec. 2015), pp.35-38, 4 p.
Publisher
University of Baghdad al-Kindi College of Medicine
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
4
Main Subjects
Abstract EN
Background: ;Hepatitis C virus (HCV) is a major cause of chronic liver disease.
Approximately 85% of patients acutely infected with HCV progress to chronic liver disease with persistence of HCV-RNA for more than 6 months Among patients with chronic HCV infection , 15-20% progress to end-stage liver disease main transmission methods of the virus is by : blood and blood products ; sharing needles and acupuncture .
Objective: To evaluate Iraqi patients infected with chronic HCV, including their treatment, and factors that affect their response to treatment .
Methods :This study was performed at Gastroenterology and Hepatology hospital in Baghdad from January 2011 to March 2012.The study enrolled 90 patients with HCV Antibody positive (Ab +ve) , every patient subjected to thorough history taking and clinical examination, and complete investigations , some of the patients subjected to liver biopsy which is analyzed by Ishak classification , the data analyzed by chi square and P value <0.05 considered statistically significant..All these patients were treated with peg interferon alpha2a given once weekly and ribavirin given in two doses daily and follow up the patients during treatment regimen.
Results: Ninety patients were enrolled, 66(73.3%) patients were male,24(26.7%) patients were female, patient age range from 18-63,mean age 41.4 year .The predominant genotype is genotype 1:45 (50%) patients , genotype 4:33(36.7%) patients .Only 27(30%)patients have viral load more than 600,000U\ml while 63(70%) Patients have viral load less than 600,000U\ml .34(37.7%) patients showed End treatment virological response.39 (42.2%) patients had been subjected to liver biopsy including those genotype 1 and4.There was a significant association between viral load and liver enzymes .
Conclusion: There is a relatively low complete response to the treatment regimen for hepatitis C .
Most of our patient with hepatitis C are discovered accidently, Most of them are male , young or middle age , asymptomatic or have minimal symptom , have low viral load .The commonest genotype is 1(50%) followed by genotype 4(36.7%) .Early virologic response were seen in most of the patients while end treatment response were seen in only 37.78%
American Psychological Association (APA)
Muhsin, Layth H.& al-Akayshi, Ragad J.& Mhawis, Ali A.. 2015. Evaluation study of patients infected with Chronic Hepatitis C in Iraq. al-Kindy College Medical Journal،Vol. 11, no. 2, pp.35-38.
https://search.emarefa.net/detail/BIM-689694
Modern Language Association (MLA)
Muhsin, Layth H.…[et al.]. Evaluation study of patients infected with Chronic Hepatitis C in Iraq. al-Kindy College Medical Journal Vol. 11, no. 2 (2015), pp.35-38.
https://search.emarefa.net/detail/BIM-689694
American Medical Association (AMA)
Muhsin, Layth H.& al-Akayshi, Ragad J.& Mhawis, Ali A.. Evaluation study of patients infected with Chronic Hepatitis C in Iraq. al-Kindy College Medical Journal. 2015. Vol. 11, no. 2, pp.35-38.
https://search.emarefa.net/detail/BIM-689694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 37-38
Record ID
BIM-689694