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Novel biomarkers for pulmonary hypertension in children with ventricular septal defect
Joint Authors
Abd al-Karim, Ahmad Muhsin
al-Hadi, Marwah
al-Dahshan, Tariq Abd al-Karim
Zayid, Khalid Mahmud Salim
Source
Egyptian Pediatric Association Gazette
Issue
Vol. 64, Issue 2 (30 Jun. 2016), pp.61-68, 8 p.
Publisher
Egyptian Pediatric Association
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background : Children with congenital heart disease (CHD) who have relevant systemicto- pulmonary shunts will develop pulmonary hypertension (PH) if untreated.
With advances in medical research, new biomarkers representing different physiological processes continue to emerge, providing an ever clearer risk profile for patients with PH.
Aim: To evaluate the role of serum galectin-3 and heart fatty acid binding protein (H-FABP) as early predictive biomarkers of PH in children with ventricular septal defect (VSD).
Method: The study included 50 children with VSD; 24 of them had PH and 25 age and sex matched healthy children serve as a control group.
Serum levels of galectin-3, H-FABP and echocardiography evaluation were done for all cases and control subjects.
We investigated the correlation between these markers and pulmonary pressure in children with VSD.
Results: Serum levels of galectin-3 and H-FABP were significantly higher in patients with PH.
There was a significant positive correlation between both markers and pulmonary pressure.
Galectin-3 and H-FABP have 76%, 60% sensitivity and 80%, 96% specificity respectively for prediction of PH in children with VSD.
Conclusion: Galectin-3 and H-FABP are promising cardiac biomarker for prediction and risk stratification of PH in children with VSD.
American Psychological Association (APA)
Zayid, Khalid Mahmud Salim& Abd al-Karim, Ahmad Muhsin& al-Hadi, Marwah& al-Dahshan, Tariq Abd al-Karim. 2016. Novel biomarkers for pulmonary hypertension in children with ventricular septal defect. Egyptian Pediatric Association Gazette،Vol. 64, no. 2, pp.61-68.
https://search.emarefa.net/detail/BIM-691918
Modern Language Association (MLA)
Abd al-Karim, Ahmad Muhsin…[et al.]. Novel biomarkers for pulmonary hypertension in children with ventricular septal defect. Egyptian Pediatric Association Gazette Vol. 64, no. 2 (Jun. 2016), pp.61-68.
https://search.emarefa.net/detail/BIM-691918
American Medical Association (AMA)
Zayid, Khalid Mahmud Salim& Abd al-Karim, Ahmad Muhsin& al-Hadi, Marwah& al-Dahshan, Tariq Abd al-Karim. Novel biomarkers for pulmonary hypertension in children with ventricular septal defect. Egyptian Pediatric Association Gazette. 2016. Vol. 64, no. 2, pp.61-68.
https://search.emarefa.net/detail/BIM-691918
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 67-68
Record ID
BIM-691918