Serum levels of 25 (OH)‎ vitamin D and immunoglobulin E in infants with bronchiolitis

Abstract EN

Vitamin D status has a great effect on respiratory health throughout the lifespan.

The aim of this study: The aim of this study was to estimate and find the relationship between both 25(OH) vitamin D and immunoglobulin E serum levels and bronchiolitis in infancy.

Methods: We quantified serum 25(OH) D and serum immunoglobulin E using (ELISA) in 50 infants with bronchiolitis and 31 healthy controls of matched age and sex.

Results: The mean serum 25(OH) vitamin D was significantly lower in cases than in controls; it was (12.3± 3.9 & 26.2± 10.0 ng/ml, respectively with p= 0.003).

The mean serum IgE was significantly higher in cases than in controls; It was (170± 66 & 43.8 ± 14.2 IU/ml, respectively and p= 0.01).

Serum IgE showed a non-significant negative correlation with serum 25(OH) vitamin D (r = 0.141, p=>0.05).

Conclusions: Serum 25(OH) vitamin D was found in decreased quantities in infants with bronchiolitis and it was negatively correlated with serum IgE, suggesting that vitamin D may play a role in the pathogenesis of bronchiolitis.