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The correlation of lipocalin-2 and retinol binding protein-4 with the inflammatory state in Iraqi patients with T2DM
Other Title(s)
العلاقة بين مستويات Lipocalin-2 و Retinol binding protein-4 و الحالة الالتهابية في العراقيين المصابين بمرض السكري من النوع الثاني
Joint Authors
Abd al-Wadud, Shadha
al-Shawk, Rafif Subayh Jamal
Sabir, Shahla Fadil
Source
Issue
Vol. 57, Issue 2A (30 Jun. 2016), pp.802-807, 6 p.
Publisher
University of Baghdad College of Science
Publication Date
2016-06-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Topics
Abstract EN
Adipokines are associated with insulin resistance and obesity-related metabolic disorders in many diseases.
The levels of Lipocalin-2 and Retinol binding protein-4 were evaluated in sera of patients with Type 2 diabetes (T2DM) to study the association between them and the inflammatory state as established by high levels of C - reactive protein and with atherogenicity.
Serum Lipocalin-2 and Retinol binding protein-4 levels measured in 73 subjects: 48 patients with T2DM with the mean level of C- reactive protein 23.989 mg/dL.
For comparison, 25 age- and gender-matched control participants enrolled with C- reactive protein CRP level 1.476 mg/dL.
The results showed that circulating Lipocalin-2, and Retinol binding protein-4 levels were significantly higher in T2DM patients when compared with that of the control group (78.688vs.38.463ng/mL) and (0.0499vs.0.041μg/mL; P<0.05) respectively.
Serum lipocalin-2 levels of patients group were negatively associated with RBP-4 (r= -0.248; P<0.039), and positively correlated with CRP (r=0.512; P<0.005) and with atherogenic index (AIP).
Lipocalin-2, but not RBP-4, was independently associated with inflammatory state and atherogenicity that confirm the presence of cardiovascular diseases risk.
A study with a large number of patients is needed to determine serum lipocalin-2 value as an early predictor for the development of cardiovascular diseases in type 2 diabetes patients
American Psychological Association (APA)
Abd al-Wadud, Shadha& al-Shawk, Rafif Subayh Jamal& Sabir, Shahla Fadil. 2016. The correlation of lipocalin-2 and retinol binding protein-4 with the inflammatory state in Iraqi patients with T2DM. Iraqi Journal of Science،Vol. 57, no. 2A, pp.802-807.
https://search.emarefa.net/detail/BIM-691996
Modern Language Association (MLA)
Abd al-Wadud, Shadha…[et al.]. The correlation of lipocalin-2 and retinol binding protein-4 with the inflammatory state in Iraqi patients with T2DM. Iraqi Journal of Science Vol. 57, no. 2A (2016), pp.802-807.
https://search.emarefa.net/detail/BIM-691996
American Medical Association (AMA)
Abd al-Wadud, Shadha& al-Shawk, Rafif Subayh Jamal& Sabir, Shahla Fadil. The correlation of lipocalin-2 and retinol binding protein-4 with the inflammatory state in Iraqi patients with T2DM. Iraqi Journal of Science. 2016. Vol. 57, no. 2A, pp.802-807.
https://search.emarefa.net/detail/BIM-691996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 805-807
Record ID
BIM-691996