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Spectrophotometric determination of carbamazepine via oxidative coupling reaction with 2,4-dinitrophenyl hydrazine
Other Title(s)
التقدير الطيفي للكاربامازيبين بوساطة تفاعل الإزدواج التأكسدي مع 4,2 –ثنائي نايترو فنيل هيدرازين
Joint Authors
Fadil, Sahar Rayhan
Dawud, Intizar Sulayman
Abd Allah, Najwa Ishaq
Source
Ibn al-Haitham Journal for Pure and Applied Science
Issue
Vol. 29, Issue 1 (30 Apr. 2016), pp.226-238, 13 p.
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2016-04-30
Country of Publication
Iraq
No. of Pages
13
Main Subjects
Topics
Abstract EN
An accurate and sensitive spectrophotometric method has been developed for the determination of carbamazepine (CRN.) in pure and dosage forms.
The method is based on the oxidation of 2,4-dinitrophenylhydrazine (2,4-DNPHz) by potassium periodate than coupling with carbamazepine (CRN.) in alkaline medium to form a stable yellowish brown colored water-soluble dye with a maximum absorption at 485 nm.
The variables that affect the completion of reaction have been carefully optimized.
Beer’s law is obeyed over the concentration range of (4-50 μg.mL-1) with molar absorptivity of (6.7335×103 L.mol-1.cm- 1).
The limit of detection was (0.1052 μg.mL-1) and Sandell’s sensitivity value was 0.0350 μg.cm-2.The proposed method has been applied successfully to the determination of carbamazepine in pharmaceutical preparation.
American Psychological Association (APA)
Fadil, Sahar Rayhan& Abd Allah, Najwa Ishaq& Dawud, Intizar Sulayman. 2016. Spectrophotometric determination of carbamazepine via oxidative coupling reaction with 2,4-dinitrophenyl hydrazine. Ibn al-Haitham Journal for Pure and Applied Science،Vol. 29, no. 1, pp.226-238.
https://search.emarefa.net/detail/BIM-692700
Modern Language Association (MLA)
Fadil, Sahar Rayhan…[et al.]. Spectrophotometric determination of carbamazepine via oxidative coupling reaction with 2,4-dinitrophenyl hydrazine. Ibn al-Haitham Journal for Pure and Applied Science Vol. 29, no. 1 (2016), pp.226-238.
https://search.emarefa.net/detail/BIM-692700
American Medical Association (AMA)
Fadil, Sahar Rayhan& Abd Allah, Najwa Ishaq& Dawud, Intizar Sulayman. Spectrophotometric determination of carbamazepine via oxidative coupling reaction with 2,4-dinitrophenyl hydrazine. Ibn al-Haitham Journal for Pure and Applied Science. 2016. Vol. 29, no. 1, pp.226-238.
https://search.emarefa.net/detail/BIM-692700
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 232-237
Record ID
BIM-692700