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Fanconi syndrome induced by tenofovir : a case report
Joint Authors
Sidqi, M. M.
Lify, Bushra
Dabo, G.
Nascimento, O.
Iraqui, S.
Elkhayat, S.
Zamd, M.
Benghanem, M.
Ramadani, B.
Marih, L.
Chakib, A.
al-Filali Marhum, K.
Medkouri, G.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 27, Issue 4 (31 Aug. 2016), pp.808-811, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2016-08-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
Abstract EN
Tenofovir disoproxil fumarate (TDF) is a nucleotide reverse transcriptase inhibitor discovered in the USA in 2001.
It is currently the treatment of choice for patients co-infected with human immunodeficiency virus (HIV) and hepatitis B virus.
Its antiretroviral efficacy and good tolerance are responsible for the higher frequency of prescriptions compared with other nucleoside analogs.
However, it can induce acute renal toxicity causing impairment of the proximal tubular function of the kidney.
This is highly dependent on factors such as associated co-prescription didanosine or a protease inhibitor “boosted” with ritonavir, preexisting renal insufficiency, low body weight, or presence of associated diabetes.
In contrast, long-term renal toxicity remains highly debated.
Some studies describe a decrease in estimated glomerular filtration rate during prolonged treatment with TDF.
Others reported renal safety even during prolonged use.
The differences between patients enrolled in the different studies, the measured parameters and their interpretation could explain these discrepancies.
We describe a case of a patient infected with HIV, who presented with Fanconi syndrome with acute renal failure six months after starting antiretroviral treatment including tenofovir
American Psychological Association (APA)
Lify, Bushra& Dabo, G.& Nascimento, O.& Iraqui, S.& Elkhayat, S.& Zamd, M.…[et al.]. 2016. Fanconi syndrome induced by tenofovir : a case report. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 4, pp.808-811.
https://search.emarefa.net/detail/BIM-693162
Modern Language Association (MLA)
Lify, Bushra…[et al.]. Fanconi syndrome induced by tenofovir : a case report. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 4 (Jul. / Aug. 2016), pp.808-811.
https://search.emarefa.net/detail/BIM-693162
American Medical Association (AMA)
Lify, Bushra& Dabo, G.& Nascimento, O.& Iraqui, S.& Elkhayat, S.& Zamd, M.…[et al.]. Fanconi syndrome induced by tenofovir : a case report. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 4, pp.808-811.
https://search.emarefa.net/detail/BIM-693162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 811
Record ID
BIM-693162