Synthesis and in vitro study of some fused 1, 2, 4- triazole derivatives as antimycobacterial agents
Joint Authors
Gupta, Supriya
Seelam, Nareshvarma
Shrivastava, S. P.
Prasanthi S.
Source
Journal of Saudi Chemical Society
Issue
Vol. 20, Issue 4 (31 Jul. 2016), pp.411-418, 8 p.
Publisher
Publication Date
2016-07-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Abstract EN
Because of the highly therapeutic nature of 1,2,4-triazoles, a new class of fused pyrazolo [30,40:4,5] thiazolo [3,2-b] [1,2,4]-triazole, isoxazolo [30,40:4,5] thiazolo [3,2-b] [1,2,4]-triazole moieties were prepared from the novel conventional methods via the reaction of 4-methyl benzoyl thiosemicarbazide with the appropriate chemical reagents.
These compounds were screened for their antimicrobial activity against various bacterial and fungal strains.
With the reference of antimicrobial activity data the synthesized compounds were further screened for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv by the conventional methods.
Among the synthesized compounds 4b, 4d, 4h, 5d and 5h have shown more activity compared to the standard drugs.
American Psychological Association (APA)
Seelam, Nareshvarma& Shrivastava, S. P.& Prasanthi S.& Gupta, Supriya. 2016. Synthesis and in vitro study of some fused 1, 2, 4- triazole derivatives as antimycobacterial agents. Journal of Saudi Chemical Society،Vol. 20, no. 4, pp.411-418.
https://search.emarefa.net/detail/BIM-693317
Modern Language Association (MLA)
Seelam, Nareshvarma…[et al.]. Synthesis and in vitro study of some fused 1, 2, 4- triazole derivatives as antimycobacterial agents. Journal of Saudi Chemical Society Vol. 20, no. 4 (Jul. 2016), pp.411-418.
https://search.emarefa.net/detail/BIM-693317
American Medical Association (AMA)
Seelam, Nareshvarma& Shrivastava, S. P.& Prasanthi S.& Gupta, Supriya. Synthesis and in vitro study of some fused 1, 2, 4- triazole derivatives as antimycobacterial agents. Journal of Saudi Chemical Society. 2016. Vol. 20, no. 4, pp.411-418.
https://search.emarefa.net/detail/BIM-693317
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 417-418
Record ID
BIM-693317