Synthesis, spectral studies, in vitro and molecular docking studies of novel hydrazinyl carbothioamide derivatives
Joint Authors
Rajalakshmi, Chinnaraja R.
Rajalakshmi, R.
Source
Journal of Saudi Chemical Society
Issue
Vol. 20, Issue 4 (31 Jul. 2016), pp.443-449, 7 p.
Publisher
Publication Date
2016-07-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Five novel compounds possessing hydrazinyl carbothioamide moiety were designed and synthesized.
All the compounds were tested for in vitro biological activities.
Most of the tested compounds displayed strong antibacterial and antifungal activities.
Molecular docking studies suggested that the hydrazinyl carbothioamide moiety of compounds (6–10) can in general be accommodated the binding pocket of the breast cancer protein (1JNX) and are responsible for the activity of the whole of the molecule.
The docking results provide a new insight into the design of hydrazinyl carbothioamide derivatives as breast cancer drug.
American Psychological Association (APA)
Rajalakshmi, Chinnaraja R.& Rajalakshmi, R.. 2016. Synthesis, spectral studies, in vitro and molecular docking studies of novel hydrazinyl carbothioamide derivatives. Journal of Saudi Chemical Society،Vol. 20, no. 4, pp.443-449.
https://search.emarefa.net/detail/BIM-693332
Modern Language Association (MLA)
Rajalakshmi, Chinnaraja R.& Rajalakshmi, R.. Synthesis, spectral studies, in vitro and molecular docking studies of novel hydrazinyl carbothioamide derivatives. Journal of Saudi Chemical Society Vol. 20, no. 4 (Jul. 2016), pp.443-449.
https://search.emarefa.net/detail/BIM-693332
American Medical Association (AMA)
Rajalakshmi, Chinnaraja R.& Rajalakshmi, R.. Synthesis, spectral studies, in vitro and molecular docking studies of novel hydrazinyl carbothioamide derivatives. Journal of Saudi Chemical Society. 2016. Vol. 20, no. 4, pp.443-449.
https://search.emarefa.net/detail/BIM-693332
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 449
Record ID
BIM-693332