Kinetics and mechanistic approach to the chromic acid oxidation of L-tryptophan with a spectral detection of chromium (III) product
Joint Authors
Fawzi, A.
Ashur, S. S.
Muslih, M. A.
Asghar, B. H.
Hassan, R. M.
Source
Journal of Saudi Chemical Society
Issue
Vol. 20, Issue 4 (31 Jul. 2016), pp.450-458, 9 p.
Publisher
Publication Date
2016-07-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
- Physics
- Oxidation
- Aldehydes
- Mathematical models
- Mechanics
- Thermodynamics
- Dynamics
- Quantum theory
- Amino acids
Abstract EN
The kinetics of chromic acid oxidation of L-tryptophan in H2SO4 medium at a constant ionic strength of 0.6 mol dm3 and at 25 C have been investigated spectrophotometrically.
The reaction exhibits a 3:2 stoichiometry (tryptophan:chromic acid).
The reaction shows a first order dependence on [chromic acid], a fractional-first order dependence on [tryptophan] and fractionalsecond order dependence on [acid].
Increasing ionic strength and dielectric constant had no significant effect on the oxidation rate.
The final oxidation products of tryptophan were identified as the corresponding aldehyde (indole-3-acetaldehyde), ammonium ion and carbon dioxide.
A spectral evidence for the formation of chromium(III) product was obtained.
The experimental results suggest formation of an intermediate complex between the protonated tryptophan and chromic acid which decomposes in the rate-determining step to yield the products.
The mechanism of such reaction has been proposed.
The thermodynamic parameters with respect to the first step of the suggested mechanism were evaluated and discussed.
American Psychological Association (APA)
Fawzi, A.& Ashur, S. S.& Muslih, M. A.& Hassan, R. M.& Asghar, B. H.. 2016. Kinetics and mechanistic approach to the chromic acid oxidation of L-tryptophan with a spectral detection of chromium (III) product. Journal of Saudi Chemical Society،Vol. 20, no. 4, pp.450-458.
https://search.emarefa.net/detail/BIM-693335
Modern Language Association (MLA)
Fawzi, A.…[et al.]. Kinetics and mechanistic approach to the chromic acid oxidation of L-tryptophan with a spectral detection of chromium (III) product. Journal of Saudi Chemical Society Vol. 20, no. 4 (Jul. 2016), pp.450-458.
https://search.emarefa.net/detail/BIM-693335
American Medical Association (AMA)
Fawzi, A.& Ashur, S. S.& Muslih, M. A.& Hassan, R. M.& Asghar, B. H.. Kinetics and mechanistic approach to the chromic acid oxidation of L-tryptophan with a spectral detection of chromium (III) product. Journal of Saudi Chemical Society. 2016. Vol. 20, no. 4, pp.450-458.
https://search.emarefa.net/detail/BIM-693335
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 456-457
Record ID
BIM-693335