Protective effects of linseed oil against methotrexate induced genotoxicity in bone marrow cells of albino mice mus musculus

Abstract EN

The genotoxic actions of anti-neoplastic drugs can lead to the development of secondary cancers in patients in extended remission.

One of the most attractive approaches to disease prevention involves the use of natural antioxidants to protect tissue against toxic injury.

The present investigation was undertaken to study the possible protective effect of linseed oil against methotrexate MTX induced chromosomal aberrations in single dose.

The animals were randomly divided into four groups consisting of five mice.

first group remain as control, second group was received single intraperitoneally injection of MTX (10 mg/kg -b .w.) to induce genotoxicity as positive control also a group of Mice treated with linseed oil (0.1ml/kg b.w.

/day) only.

Last group was treated orally with linseed oil (0.1ml/kg b.w.

/day) prior to an interperitoneal dose of MTX by three hours for fifteen days.

MTX have ability to induce various types of chromosomal aberrations such as (Chromosome break, Chromatid break, Centromeric break, fragments), The results explored that linseed oil possesses significant protective potential against Methotrexate by decreasing chromosomal aberration frequency in bone marrow cells.