PCR- based quantification of exon 21 in BRCA2 gene in breast cancer patients in Erbil Province

Abstract EN

Breast cancer affects mainly women and the leading cause of women fatality in the worldwide.

The breast cancer is many ways sporadic and the hereditary types, it constitutes about 20% in many populations.

BRCA2 function as a tumor suppressor gene and is important in maintenance of genomic stability through its role in DNA damage signaling and DNA repair, it is located on chromosome 13q12.3.

In this study, 32 normal control samples and 35 breast cancer samples that were grouped according to the types of breast cancer and clinical characteristics of patients, including average age were observed with PCR-based quantification analysis.

The quantity of BRCA2 gene in breast cancer samples was highly significance (p > 0.00) decreased as compare with normal samples.

In conclusion, the declined quantity of BRCA2 gene might be a risk factor for breast cancer development.

In order to understand relationships between BRCA2 gene and breast cancer, Further studies are necessary.