Efficacy of traditional medicine product henna and hydrocortisone on diaper dermatitis in infants

Abstract EN

Background: Diaper dermatitis (DD) is a common inflammatory disorder in infants, including newborns.

Objectives: This study aimed to compare the effects of a traditional medicine product (containing natural henna oil 25%) and hydrocortisone 1% cream on DD in infants.

PatientsandMethods: In a triple-blind, randomizedtrial, 82 children agedtwoyears or lesswererandomlydivided intotwogroups of 41 children each to receive either hydrocortisone ointment or henna medicinal product.

Infants were treated 3 times a day for 5 days.

The severity of dermatitis was assessed on the first, third, and fifth days using a six-point scale.

The study was conducted in 2013 in a children teaching hospital in Qazvin, Iran.

Results: Both groups showed an improvement in the severity of DD (mean DD severity on the first, third and fifth days, respectively, was 3.20, 1.39, and 1.20 in the henna group versus 3.20, 2.05, and 1.90 in the hydrocortisone group; P < 0.001).

The henna group showed a better response when compared with the hydrocortisone group: the rate of improvement on the fifth day of treatment was 90.2% (37 of 41 children without erythema) in the former versus 61% (25 of 41 patients) in the latter (P = 0.042).

No significant side effects were observed in both the groups.

Conclusions: Henna, a traditional medicine product, can be considered an effective and appropriate treatment for DD in infants and children.