Design, synthesis and kinetic study of coumarin-based mutual prodrug of 5-fluorouracil and dichloroacetic acid
Other Title(s)
تصميم و تصنيع، و دراسة حركية بادئ الدواء التبادلي المرتكز على الكومارين ل5- فلورويراسيل و ثنائي الكلور حامض الخليك
Joint Authors
Mustafa, Yasir Fakhri
al-Umari, Nihad Abd al-Wahhab
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 25, Issue 1 (30 Jun. 2016), pp.6-16, 11 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2016-06-30
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Topics
Abstract EN
On the basis of known coumarin-based prodrug system, a novel coumarin-based mutual prodrug of 5-fluorouracil and dichloroacetic acid was designed, synthesized and evaluated as a promising oral chemotherapeutic agent basing on in vitro stability study in HCl buffer (pH 1.2) and in phosphate buffer (pH 7.4), as well as in vitro release study in human serum.
The chemical structure of prodrug was confirmed by analyzing its FTIR, 1H NMR, 13C NMR and MS-ESI spectra.
The results of in vitro kinetic study indicated that the prodrug was significantly stable in HCl and in phosphate buffers, and was hydrolyzed in human serum followed pseudo first order kinetics.
American Psychological Association (APA)
Mustafa, Yasir Fakhri& al-Umari, Nihad Abd al-Wahhab. 2016. Design, synthesis and kinetic study of coumarin-based mutual prodrug of 5-fluorouracil and dichloroacetic acid. Iraqi Journal of Pharmaceutical Sciences،Vol. 25, no. 1, pp.6-16.
https://search.emarefa.net/detail/BIM-695792
Modern Language Association (MLA)
Mustafa, Yasir Fakhri& al-Umari, Nihad Abd al-Wahhab. Design, synthesis and kinetic study of coumarin-based mutual prodrug of 5-fluorouracil and dichloroacetic acid. Iraqi Journal of Pharmaceutical Sciences Vol. 25, no. 1 (2016), pp.6-16.
https://search.emarefa.net/detail/BIM-695792
American Medical Association (AMA)
Mustafa, Yasir Fakhri& al-Umari, Nihad Abd al-Wahhab. Design, synthesis and kinetic study of coumarin-based mutual prodrug of 5-fluorouracil and dichloroacetic acid. Iraqi Journal of Pharmaceutical Sciences. 2016. Vol. 25, no. 1, pp.6-16.
https://search.emarefa.net/detail/BIM-695792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 15-16
Record ID
BIM-695792