Blood pressure and atrial natriuretic peptide (ANP)‎ levels in patients with autosomal dominant polycystic kidney disease

Abstract EN

Autosomal dominant polycystic kidney disease (ADPKD) is the most common life threatening hereditary disease of the kidney.

It is a systemic disease characterized by multiple, bilateral renal cysts that result in massive renal enlargement and progressive functional impairment.

Patients with ADPKD often develop hypertension before any abnormalities in renal function are detected clinically.

In particular, hypertension is insidious and remains a continuous problem that evolves during the course of the disease.

Atrial natriuretic peptide (ANP) possess bioactive on blood pressure.

This study dealt with two groups of patients with ADPKD; the first included the patients with renal failure while the other included the patients without renal failure, as well as healthy control group.

The results found prevalence of hypertension in patients with ADPKD, reached 75%.

Blood pressure was significant increase (P≤0.05) in ADPKD patients without renal failure than control, where reached to 137.14/85 mmHg compared with 123.93/80.71 mmHg respectively.

The ANP levels were significant increase (P≤0.05) in ADPKD patients with renal failure compared with ADPKD patients without renal failure and control groups, which reached (106.5 pg/ml), (79.2 pg/ml) and (24.4 pg/ml) respectively.