Ppotential affinity binding of sarcophine to dna

Abstract EN

Sarcophine is a natural product isolated from the Red Sea soft coral Sarcophyton glaucum and other sarcophyton species.

It has a cembranolide diterpene structure.

Sarcophine was shown to possess numerous biological activities including a potent antitumorigenicity.

The interaction between sarcophine and nucleic acids was not studied yet.

This warranted a study of its potential chemical affinity to DNA.

In the current investigation, the in-vitro effects of sarcophine on DNA were studied.

Different concentrations of sarcophine were added to DNA followed by the electrophoretic mobility shift assay and the UV-spectrophotometric measurements.

The results of this study showed that the natural toxin sarcophine has a high binding affinity towards double stranded DNA.

These findings may help in understanding the mechanism of the anti-tumorigenic activity of sarcophine.