Role of some cytokines and oxidative stress enzymes in Iraqi children infected with visceral leishmaniasis

Abstract EN

A totals of 66 children whose ages range from seven month to six years, suspected to be infected with Visceral Leishmaniasis (VL), they were compared to fifty healthy subjects in the control group.

The diagnosis was done by rKE16 dipstick test, and evaluating the level of cytokine IL-6, Intercellular Adhesion Molecule (ICAM-1) and Monokine induced by INF-ɣ (MIG-1), was evaluated.

Stress biomarkers estimate including the level of malondialdehyde (MDA) as an index of free radicals induced lipid peroxidation and catalase as an index of antioxidant enzyme in the serum of patients infected with VL.

The rKE16 antigen strip test shows valid highly in the diagnosis (N=65) of suspected children with VL.

The test rapid, sensitive, and specific .The results show an increase (P≤0.05) in the serum levels of IL‐6, ICAM and MIG-1 in patients than in healthy subject.

Result of oxidative stress showed a significant (P≤ 0.005) elevated level of MDA and a decrease CAT in patients with VL as compared to the cases in the control.

These results showed points in the pathology of VL and might open new treatment perspectives associated with antioxidant.