Interaction of insulin hormone with microalbuminuria and blood pressure in type 2 diabetic patients

Abstract EN

This study aimed to evaluate the interaction between insulin hormone with microalbuminuria and blood pressure in type 2 diabetic patients.

The results of this study showed that patients with diabetic of both male and female have significant elevation ( p ≤ 0.05 ) in insulin hormone levels, insulin resistance ,fasting blood glucose (FBG) and microalbuminuria than control group.

Insulin sensitivity show significant decrease in diabetic group when compared with control group.

There are no significant differences in blood pressure in diabetic group when compared with control group.

According to the duration of disease the results showed that microalbuminuria exert significant elevation in the fourth duration (> 15) years of disease when compared with other duration and with the increase in the duration of diabetic , the fasting blood glucose (FBG) values showed a significant increase than the lower duration of diabetic.Insulin sensitivity values showed a significant decrease in the fourth duration (> 15) years of disease when compared with other duration .

The correlation analysis showed that there were positive significant correlation between insulin and microalbuminuria in both genders in diabetic group , while there is an positive correlation between insulin and systolic pressure in males.

Conclusions: In diabetic patients ,hyperinsulinemia cause elevation in microalbuminuria and this increase the risk of development of nephropathy and progression of cardiovascular disease.