Hemostatic parameters in Thalassemia patients; a single institute experience
Author
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 58, Issue 2 (30 Jun. 2016), pp.132-135, 4 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2016-06-30
Country of Publication
Iraq
No. of Pages
4
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background: Changes of coagulation profile have been described in patients with B-Thalassemia major.
Prolongation of prothrombin time and partial thromboplastin time and reduced levels of coagulation factors and natural anticoagulants have been variously described though the mechanisms involved in the thrombotic tendency seen in some Thalassemia patients have not been fully clarified.
Objectives: To investigate changes in the coagulation profile in patients with B-Thalassemia according to the available hemostatic parameters in Thalassemia patients in Al-Karama Teaching Hospital in Wasit governorate.
Methods: Hemostatic variables were studied in pre-transfusion blood samples from 50 transfusion-dependent children with Beta Thalassemia (mean age 13.2 years) and from 20 healthy controls.
Results: Laboratory evaluation showed thrombocytopenia in 43.5%, prolongation of prothrombin time (PT) in 54% and prolongation of activated partial thromboplastin time (aPTT) in 56% of the patients.
All measured coagulation factors level were low in activity as compared with control group.
Serum ferritin had positive correlation with PTT and PT (r=0.12 and r=0.11 respectively) and significant negative correlation with platelet count (r=-0.3).
Conclusions: Changes in the hemostasis in Thalassemia patients is notifiable.These laboratory finding may be subclinical, but play important role in anticipation of future hemorrhagic manifestation and thrombotic events
American Psychological Association (APA)
Faraj, Safa A.. 2016. Hemostatic parameters in Thalassemia patients; a single institute experience. Journal of the Faculty of Medicine Baghdad،Vol. 58, no. 2, pp.132-135.
https://search.emarefa.net/detail/BIM-698143
Modern Language Association (MLA)
Faraj, Safa A.. Hemostatic parameters in Thalassemia patients; a single institute experience. Journal of the Faculty of Medicine Baghdad Vol. 58, no. 2 (2016), pp.132-135.
https://search.emarefa.net/detail/BIM-698143
American Medical Association (AMA)
Faraj, Safa A.. Hemostatic parameters in Thalassemia patients; a single institute experience. Journal of the Faculty of Medicine Baghdad. 2016. Vol. 58, no. 2, pp.132-135.
https://search.emarefa.net/detail/BIM-698143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 135
Record ID
BIM-698143