Immunohitochemical expression of Bcl-2in human colocrectal carcinoma
Joint Authors
Shakir, Hind H.
al-Tai, Tharwa H. Hasan
Abd al-Ghafur, Kifah H.
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 58, Issue 2 (30 Jun. 2016), pp.165-169, 5 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2016-06-30
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Abstract EN
Background: Colorectal carcinoma is the most frequent type of malignancy in terms of incidence,it is the third most common cancer world wide in both sexes .
bcl_2 expression has been described as been a better prognostic factor in colorectal carcinoma.
Objcetives: To determine the frequency and the pattern of Bcl-2 expression in colorectal carcinoma by immunohistochemical technique and to correlate this expression with different clinicopathological parameters.
Material and method: Thirty cases of colorectal carcinoma were studied, these cases were diagnosed in private laboratories in Baghdad / Iraq from January 2015 to Juan 2015.
Clinicopathological parameter such as age, gender , pathological diagnosis , tumor site , lymph nodes status , grade and stage of tumor were collected from patients files..Sections of 4μm were stained by hematoxylen and eosin stain, and immunohistochemical stained for Bcl-2.
Results: Nineteen (63.3%) cases were males, 11(36.7%) cases were females, with age distribution ranging from (39-89) years with a mean age of 56.5 years.
Histologically the tumor grade range from moderately differentiated in 27 (90%) cases and poorly differentiated in 3 (10%) cases.
Ten (33.3%)cases located in the right colon and sigmoid each 6(20%) cases in rectum,8(26.7%) cases in the cecum,3(10%)cases located in right colon and sigmoid each,6(20%) cases in the rectum and 8(26.7%) cases in the left colon.
Regarding pathological staging (TNM system),2 (6.7%) cases were stage T2 ,24 (80%) were stage T3 ,4(13.3%) cases were T4.
Lymph node involvement found in 14(46%) cases and distant metastasis was found in 9(30%) cases.
Bcl-2 expression was present in 14(46.7 %) cases of 30 colorectal carcinoma.There was no significant correlation with age, sex, histopathological grade, location, lymph nodes status and tumor invation.
Conclusion: There was no significant statistical correlation between bcl expression by tumor cell of colorectal carcinoma and different clinicopathological parameters in this study.
American Psychological Association (APA)
Abd al-Ghafur, Kifah H.& al-Tai, Tharwa H. Hasan& Shakir, Hind H.. 2016. Immunohitochemical expression of Bcl-2in human colocrectal carcinoma. Journal of the Faculty of Medicine Baghdad،Vol. 58, no. 2, pp.165-169.
https://search.emarefa.net/detail/BIM-698151
Modern Language Association (MLA)
Abd al-Ghafur, Kifah H.…[et al.]. Immunohitochemical expression of Bcl-2in human colocrectal carcinoma. Journal of the Faculty of Medicine Baghdad Vol. 58, no. 2 (2016), pp.165-169.
https://search.emarefa.net/detail/BIM-698151
American Medical Association (AMA)
Abd al-Ghafur, Kifah H.& al-Tai, Tharwa H. Hasan& Shakir, Hind H.. Immunohitochemical expression of Bcl-2in human colocrectal carcinoma. Journal of the Faculty of Medicine Baghdad. 2016. Vol. 58, no. 2, pp.165-169.
https://search.emarefa.net/detail/BIM-698151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 168-169
Record ID
BIM-698151