Study the preventive effect of aqueous extract of Gingko biloba on cerebral damage induced by ischemiareperfusion in rat

Abstract EN

Background: cerebral damage may occur in a variety of clinical settings and this remains a significant problem.

Therefore, it seems possible that the administration aqueous extract of Gingko biloba might protect the brain against the ischemia reperfusion injury.

Objectives: The study included knowledge Phytochemical Composition and determine whether Gingko biloba in the aqueous extract prevents or decreases I/R brain damage.

Methods: Thirty rats were divided into three groups as control, I/R group and Gingko biloba treatment group.

Serum was used for the estimation of biochemical parameters: oxidative stress levels of nitric oxide (NO) and lipid peroxidation (LPO) and blood was used for the estimation of enzyme immunoassay: Interleukin-8 (IL-8), tumor necrosis factor Alpha (TNF-α), interleukin-1β (IL-1β).

Results: The results showed that the extract contain : glycosides , saponins ,tannins ,phenolic compounds , resins, flavonoids ,alkaloids and proteins.The levels of Oxidative stress in group 3 were significantly lower than those in group 2 as well as the levels of enzyme immunoassay in group 3 were significantly lower than those in group 2.

Conclusion: The present results suggest that Gingko biloba treatment protects the rat brain against ischemia-reperfusion brain damage.