Epstein barr virus and p53 gene expression correlation with gastric adenocarcinoma patients in Baghdad City

Abstract EN

Gastric carcinoma is the most prevalent cancer related deaths worldwide today .

The current study was carried out to shed the light on Epstein Barr virus, Tumor suppressor gene p53 associated gastric cancer of some Iraqi patients.

According to insitu hybridization technique , this study was determined EBV and p53 gene correlates with some aspects of gastric cancer patients like age, gender , histological grade and stage of the tumor .

Fourty six biopsies were obtained from patients with adenocarcinoma who had undergone gastrectomy.

The tissue sections were collected during the period between September 2010 until June 2013.

Epstein Barr virus was detected insitu hybridization in 18 patients (39%) out of 46.

Whereas, the positive results of relation between p53 oncogene and gastric adenocarcinoma patients were detected in 30 (65.2%) out of 46.

Out of 46 patients , this study included 32 male and 14 female with mean age 54 ranged between 30-72 years.

The histological types included 18 well, 4 moderate and 24 poor differentiated respectively .

Most of cases 32 (69.5%) falling in stage I-II and the remaining 14 were in the stage III and IV.

The positive results revealed that EBV correlate in highly significant association with each of age, gender, grade and stage of the tumor , also expression of tumor suppressor gene p53 was correlation with all patients aspects in highly significant association