Comparison between the cassia fistula‘s emulsion with polyethylene glycol (PEG4000) in the pediatric functional constipation : a randomized clinical trial
Joint Authors
Dooki, Muhammad Rida Ismaili
Mozaffarpur, Sayyid Ali
Mirzapour, Mohaddese
Shirafkan, Huda
Bijani, Ali
Kamalinejad, Muhammad
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 18, Issue 7 (31 Jul. 2016), pp.1-8, 8 p.
Publisher
Publication Date
2016-07-31
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Abstract EN
Background : There are few effective drugs for pediatric functional constipation (FC).
Objectives : Comparing the effectiveness of Cassia fistula’s emulsion (CFE) with Polyethylene glycol (PEG4000) in FC; and evaluation of safety of both drugs in the treatment of FC.
Materials and Methods: A randomized open label, prospective, controlled, parallel-group clinical trial was carried on 109 children (M/F: 63/46; mean age SD: 59.7 28.8 months) in Amirkola children’s hospital, Babol, Iran.
The inclusion criteria were based on diagnosis of FC according to the Rome III criteria and age range between 2 - 15 years.
They received CFE or PEG randomly for 4 weeks.
Frequencies of defecation, severity of pain, consistency of stool, fecal incontinence and retentive posturing were compared between the two groups and with baselines.
Children were counted as improved when they exited from Rome III criteria of FC.
Results: Fifty seven patients were assigned to receive PEG and 52 patients received CFE.
After 4weeks of medication, 86.5 % of children in CFE group and 77.1 % in PEG group (RR = 1.121, CI95%:0.939 - 1.338) exited from the criteria of FC.
All measurable criteria improved in both groups without any significant difference, except in the frequency of defecation that in CFE group (10.965.7)wassignificantly more than PEG group (6.9 3.5) (P < 0.0001).
Compliances of PEG were significantly better in the 2 first weeks (P = 0.002, 0.008) but not in third and fourth week (P = 0.061, 0.062).
None of these two drugs cause clinically significant side effects.
Conclusions : CFE can be as effective as PEG in the 4-weeks treatment of children with FC.
American Psychological Association (APA)
Dooki, Muhammad Rida Ismaili& Mozaffarpur, Sayyid Ali& Mirzapour, Mohaddese& Bijani, Ali& Shirafkan, Huda& Kamalinejad, Muhammad. 2016. Comparison between the cassia fistula‘s emulsion with polyethylene glycol (PEG4000) in the pediatric functional constipation : a randomized clinical trial. Iranian Red Crescent Medical Journal،Vol. 18, no. 7, pp.1-8.
https://search.emarefa.net/detail/BIM-701494
Modern Language Association (MLA)
Dooki, Muhammad Rida Ismaili…[et al.]. Comparison between the cassia fistula‘s emulsion with polyethylene glycol (PEG4000) in the pediatric functional constipation : a randomized clinical trial. Iranian Red Crescent Medical Journal Vol. 18, no. 7 (Jul. 2016), pp.1-8.
https://search.emarefa.net/detail/BIM-701494
American Medical Association (AMA)
Dooki, Muhammad Rida Ismaili& Mozaffarpur, Sayyid Ali& Mirzapour, Mohaddese& Bijani, Ali& Shirafkan, Huda& Kamalinejad, Muhammad. Comparison between the cassia fistula‘s emulsion with polyethylene glycol (PEG4000) in the pediatric functional constipation : a randomized clinical trial. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 7, pp.1-8.
https://search.emarefa.net/detail/BIM-701494
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-701494