Hepatotoxic effect of chronic exposure of tacrolimus in male albino rats
Other Title(s)
التأثيرات السمية الكبدية للتعرض المزمن لعقار التاكروليمس في ذكور الجرذان المهقاء
Joint Authors
Muhammad, Ali Ibrahim
Jabr, Ahmad Shamkhi
al-Rikabi, Falah Musa Kazim
Source
Iraqi Journal of Veterinary Medicine
Issue
Vol. 40, Issue 1 (30 Jun. 2016), pp.161-166, 6 p.
Publisher
University of Baghdad College of Veterinary Medicine
Publication Date
2016-06-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Topics
Abstract EN
This study was carried out to investigate the hepatotoxicity of chronic adminstration of an immunosuppressant Tacrolimus in male albino rats.
Thirty male albino rats were randomly divided into 3 equal groups, the first one (T1) recieved therapeutic dose (70μg/kg.BW) of Tacrolimus.
The second group (T2) recieved double dose (140 μg/kg.BW) of Tacrolimus, while the third group recieved distilled water for the same period and considered as control (C).
Alanine aminotransferase, Aspartate aminotransferases, Alkaline Phosphatase, serum potassium and serum calcium showed significant increase in both treated groups T1 and T2 as compared with control, proportional to the dose of Tacrolimus.
There were histopathological changes seen in liver at the end of exposure manifested by necrosis, hemorrhage, hyperplasia and fibrosis.It can be concluded that Tacrolimus has hepatotoxic effects when used for a long period
American Psychological Association (APA)
Muhammad, Ali Ibrahim& al-Rikabi, Falah Musa Kazim& Jabr, Ahmad Shamkhi. 2016. Hepatotoxic effect of chronic exposure of tacrolimus in male albino rats. Iraqi Journal of Veterinary Medicine،Vol. 40, no. 1, pp.161-166.
https://search.emarefa.net/detail/BIM-701667
Modern Language Association (MLA)
Muhammad, Ali Ibrahim…[et al.]. Hepatotoxic effect of chronic exposure of tacrolimus in male albino rats. Iraqi Journal of Veterinary Medicine Vol. 40, no. 1 (2016), pp.161-166.
https://search.emarefa.net/detail/BIM-701667
American Medical Association (AMA)
Muhammad, Ali Ibrahim& al-Rikabi, Falah Musa Kazim& Jabr, Ahmad Shamkhi. Hepatotoxic effect of chronic exposure of tacrolimus in male albino rats. Iraqi Journal of Veterinary Medicine. 2016. Vol. 40, no. 1, pp.161-166.
https://search.emarefa.net/detail/BIM-701667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 164-166
Record ID
BIM-701667