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Application of autologous platelet-rich plasma (PRP) onwound healing after caesarean section in high-risk patients
Joint Authors
Tehranian, Afsaneh
IsfIhani Mihr, Baharih
Pirjani, Reihaneh
Rezaei, Negar
Heidary, Somaye Sadat
Sepidarkish, Mahdi
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 18, Issue 7 (31 Jul. 2016), pp.1-8, 8 p.
Publisher
Publication Date
2016-07-31
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Abstract EN
Background : Platelet-rich plasma (PRP) is ahumanplasma product enriched by platelets, growth factors, and fibrinogen with high hemostatic and healing properties.
Objectives : The aim of this study was to evaluate the effect of autologous PRP on wound healing in high-risk women undergoing cesarean sections.
Patients and Methods : In this balanced, randomized, and controlled trial, 140 patients were admitted to Arash women’s hospital, Tehran, Iran from May of 2013 to November of 2014 for elective cesarean surgery.
The patients were randomly assigned into two groups.
The intervention group received PRP after surgery, whereas the control group received the usual care.
All patients were evaluated at baseline, five days, and eight weeks after the cesarean section.
The primary endpoint used the REEDA scale for assessing the changes in wound healing.
The secondary outcome measures used were the Vancouver scar scale (VSS) and the visual analog scale (VAS).
All scale scores were analyzed using a repeated measures test for variance.
Results : At the end of study, the PRP group showed a greater reduction in the edema ecchymosed discharge approximation (REEDA) score compared to the control group (85.5 % reduction in the PRP group; 72 % in the control group) (P < 0.001).
Compared with the control group, the PRP group had a significantly greater reduction in the VANscore, beginning on the fifth day after the cesarean section (-0.7, 38 % reduction in PRP group; -0.8, 33 % in control group) (P < 0.001), and this trend was stable at the end of the eighth week (-0.6, 54 % reduction in PRP group ; -0.3, 18 % in control group).
Furthermore, patients treated with PRP experienced a 93 % reduction in the VAS score at the end of follow-up, but the control group only observed a 79 % reduction (P < 0.001).
Conclusions : It seems that applying PRP is an effective therapeutic approach for wound healing, and faster wound healing is expected due to the presence of more platelets and growth factors.
American Psychological Association (APA)
Tehranian, Afsaneh& IsfIhani Mihr, Baharih& Pirjani, Reihaneh& Rezaei, Negar& Heidary, Somaye Sadat& Sepidarkish, Mahdi. 2016. Application of autologous platelet-rich plasma (PRP) onwound healing after caesarean section in high-risk patients. Iranian Red Crescent Medical Journal،Vol. 18, no. 7, pp.1-8.
https://search.emarefa.net/detail/BIM-701858
Modern Language Association (MLA)
IsfIhani Mihr, Baharih…[et al.]. Application of autologous platelet-rich plasma (PRP) onwound healing after caesarean section in high-risk patients. Iranian Red Crescent Medical Journal Vol. 18, no. 7 (Jul. 2016), pp.1-8.
https://search.emarefa.net/detail/BIM-701858
American Medical Association (AMA)
Tehranian, Afsaneh& IsfIhani Mihr, Baharih& Pirjani, Reihaneh& Rezaei, Negar& Heidary, Somaye Sadat& Sepidarkish, Mahdi. Application of autologous platelet-rich plasma (PRP) onwound healing after caesarean section in high-risk patients. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 7, pp.1-8.
https://search.emarefa.net/detail/BIM-701858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-701858