علاقة مستويات MASP-2 المصلبة مع نوب قلة العدلات الحموية لدى أطفال سوريين مصابين بابيضاض الدم اللمفاوي الحاد

Abstract EN

Chemotherapy-related infections remain a major cause of morbidity and mortality, Fever and severe chemotherapy-induced neutropenia (FN) represents the main reason for nonscheduled hospital admission.

Serum low levels of Mannose-binding lectin-Associated Serine Protease-2 (MASP-2) may presents a risk factor for developing febrile neutropenic attacks in patients of acute lymphoblastic leukemia who are candidates for chemotherapy Our study aimed to assess the relationship between serum MASP-2 levels and febrile neutropenic attacks in Syrian children with acute lymphoblastic leukemia (ALL).

The study has been done at Children University Hospital in Damascus between 2013-2014.

This study included 37 children diagnosed with acute lymphoblastic leukemia (ALL) who were candidates for chemotherapy, and the values of febrile neutropenic attacks were calculated depending on patient's files.

The levels of Mannose-Binding Lectin-associated Serine Protease-2 (MASP-2) were measured by Enzyme Linked Immuno Sorbent Assay (ELISA).

As a result, there was found an important inverse relationship between Febrile Neutropenic attacks and serum MASP-2 levels, and it was clear that patients with MASP-2 deficiency developed more FN attacks than patients who have normal MASP-2 levels.