Circulating micrornas : potential biomarkers in cancer detection, diagnosis and prognosis
Joint Authors
Makarim, Nadir
Murad, Ahmad
Nassar, Farah J.
Nasr, Rihab
Source
Issue
Vol. 64, Issue 2 (30 Jun. 2016), pp.116-122, 7 p.
Publisher
Publication Date
2016-06-30
Country of Publication
Lebanon
No. of Pages
7
Main Subjects
Abstract EN
A large family of small 18-25 nucleotide long non coding RNA molecules now known as microRNA (miRNA) was described two decades ago, and has been recently established as post-transcriptional gene regulators.
miRNAs were shown to be involved in the regulation of diverse physiological and developmental processes.
Moreover, dysregulation of specific miRNAs has been implicated later in several pathologies including cancer.
Owing to their presence and stability in body fluids, miRNAs have been investigated as novel circulating non-invasive biomarkers.
Accordingly, their role as potential diagnostic, prognostic or predictive biomarkers for many cancer types has recently emerged.
This review tackles the use of circulating miRNAs in cancer detection, diagnosis and prognosis, giving examples using common solid tumors and discussing the advantages of their use, the challenges facing this novel circulating biomarker and recommendations to overcome them.
Abstract FRE
Les microARN (miARNs), découverts il y a deux décennies, forment une grande famille de petites molécules d’ARNs non codants de 18 à 25 nucléotides de longueur.
Récemment, plusieurs recherches ont prouvé que les miARNs sont des régulateurs post-transcriptionnels de gènes impliqués dans la régulation du développement et de divers processus physiologiques.
De plus, la dérégulation de certains miARNs semble être à l’origine de plusieurs pathologies, dont le cancer.
En raison de leur présence et de leur stabilité dans des fluides corporels, les miARNs ont été étudiés en tant que biomarqueurs diagnostiques, pronostiques ou prédictifs non invasifs pour de nombreux types de cancer.
Cet article aborde l’utilisation des miARNs circulants dans la détection, le diagnostic et le pronostic de certaines tumeurs solides et examine les avantages de leur utilisation, les défis auxquels ces nouveaux biomarqueurs circulants feront face et certaines recommandations pour les surmonter
American Psychological Association (APA)
Makarim, Nadir& Murad, Ahmad& Nassar, Farah J.& Nasr, Rihab. 2016. Circulating micrornas : potential biomarkers in cancer detection, diagnosis and prognosis. Journal Médical Libanais،Vol. 64, no. 2, pp.116-122.
https://search.emarefa.net/detail/BIM-701958
Modern Language Association (MLA)
Makarim, Nadir…[et al.]. Circulating micrornas : potential biomarkers in cancer detection, diagnosis and prognosis. Journal Médical Libanais Vol. 64, no. 2 (Apr. / Jun. 2016), pp.116-122.
https://search.emarefa.net/detail/BIM-701958
American Medical Association (AMA)
Makarim, Nadir& Murad, Ahmad& Nassar, Farah J.& Nasr, Rihab. Circulating micrornas : potential biomarkers in cancer detection, diagnosis and prognosis. Journal Médical Libanais. 2016. Vol. 64, no. 2, pp.116-122.
https://search.emarefa.net/detail/BIM-701958
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 120-122
Record ID
BIM-701958
