Relations between vitamin D level and carotid artery intima-media thickness in adolescents with type 1 diabetes

Abstract EN

Introduction: Given that artery intima-media thickness (cIMT) has been identified as a surrogate marker for increased cardiovascular risk, it is important to determine which factors, if any, contribute to the increment of cIMT value in TIDM adolescents.

Some recent review studies concluded appreciated relation between vitamin D deficiency and development of atherosclerosis.

Objectives: to study the relation between vitamin D levels and cIMT in adolescents with TIDM Methods: The current cross sectional, case- control study included 80 subjects {40 adolescents with TIDM aged 12-18 yeas P14.56 ± 1.65 years) average glycoselated hemoglobin (HbAIC) of TIDM patients selected was >7% and forty healthy age and sex matched adolescents as a control group}.

All candidate were subjected to full clinical evaluation (including vital signs, complete systemic examination, assessment of pubertal development by Tanner staging and anthropometric measurements (weight, height, BMI and wist/hip ratio).

All the candidates had the following laboratory investigation been done (fasting blood glucose (FBG), average HbAIC, C-peptide and 25 (OH) vitamin D).

cIMT was done for all the subjects included in the study.

Results: cIMT levels were significantly higher in cases (0.051 ±0.005cm) than in healthy controls )0.045 0.006cm), P value < 0.001.

Vitamin D level was significantly lower in cases (29.500 ± 6.37 ng/dl), than in controls (40.25 ± 6.49 ng/dl), P value < 0.001.

Significant negative linear correlation was found between cIMT and vitamin D (r value 0.265 and P value 0.018).

Conclusion: Patients with type 1 diabetes has significantly increased mean (cIMT) and significantly reduced mean vitamin D level compared to the control subjects Increased (cIMT) was inversely correlated with vitamin D level.