Serum vaspin level and metabolic syndrome markers in obese children

Abstract EN

Introduction: Childhood obesity is associated with substantial co- morbidity and late sequelae, it is a major risk factor for chronic diseases and plays a central role in the insulin resistance and metabolic syndrome.

The most common underlying cause of complications is central obesity.

Insulin resistance and metabolic syndrome may be implicated in the development of many pathological states.

Aim: The purpose of this study was to asses different indices of obesity, metabolic syndrome and to study the level of serum vaspin as an indicator of insulin resistance in obese non diabetic children.

Anthropometric, clinical and laboratory assessment performed to all children.

Patients And Methods: This case- control study included 45 obese children compared to 45 healthy lean who were recruited from the outpatient clinic of the National Nutrition Institute from September 2013 to January 2014.

Results: Most of the cases 93.3% were exceeding the 90th percentile of waist circumference.

Twenty- one cases had high systolic and diastolic blood pressure over 90th percentile.

Metabolic syndrome was highly prevalent among obese children 53.3%.

Thirty- one cases were on prediabetic level of HBA1c.

Insulin resistance was detected in 47.7% of cases and acanthosis nigrican was found in 68.9% of obese children.

High serum vaspin level was found in 24 cases, with no statistical significant difference between cases and control or between male and female cases.

Conclusion: The prevalence of the metabolic syndrome is high among obese children, and it increases with worsening obesity.

Biomarkers of an increased risk of adverse cardiovascular and diabetic outcomes are already present in these children.

Body fat in obese children does not influence serum vaspin levels.