Spectrophotometric determination of celecoxib in pharmaeeutieal preparations

Abstract EN

Two simple and sensitive spectrophotometric methods have been developed for the estimation of Celecoxib in pure and pharinaceutical dosage forms.

Method A is based on ion association complex formation of the drug with M^h^ne Blue .

Method B is based on the charge transfer complexation reaction between Celecoxib and iodine.

The absorption spectrum of Celecoxib - m^h^ne blue and Celecoxib -iodine reaction products showed absorption peaks at 665 and 511 nm respectively.

The systems obeyed the Beer’s law in the range 0.2-1 jLig/ml for both the methods A and B.

The correlation coefficients and the limits of assays detection values were found to be 0.999, 0.37 for (method A) and 0.998, 0.426 for (method B).

, respectively, ?roposed methods were successfully applied to the qualitative determination of celecoxib in pharmaceutical dosage forms with good accuracy.