Design and synthesis of novel 4-substituted 1, 4-dihydropyridine derivatives as hypotensive agent
Joint Authors
Datar, Prasanna A.
Auti, Pratibha B.
Source
Journal of Saudi Chemical Society
Issue
Vol. 20, Issue 5 (30 Sep. 2016), pp.510-516, 7 p.
Publisher
Publication Date
2016-09-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
Calcium-channel blockers have an important role in the treatment of several cardiovascular disorders.
Derivatives of 1,4-dihydropyridines are one of the most potent calcium antagonists.
In this study a series of novel 1,4-dihydropyridine calcium channel blockers of general formula diethyl 4-(4-substituted phenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate were synthesized and tested for hypotensive activity, including electrocardiographic and effect on heart rate.
Compound diethyl 4-(4-benzyloxy phenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (DHP I) and diethyl 4-(2-(2-chlorobenzyloxy) phenyl)-1,4-dihydro-2,6-dimethylpyridine-3, 5-dicarboxylate (DHP III), were the most potent in this series.
All synthesized compounds lowered rat blood pressure significantly in comparison with DMSO as control and nifedipine was used as positive control
American Psychological Association (APA)
Datar, Prasanna A.& Auti, Pratibha B.. 2016. Design and synthesis of novel 4-substituted 1, 4-dihydropyridine derivatives as hypotensive agent. Journal of Saudi Chemical Society،Vol. 20, no. 5, pp.510-516.
https://search.emarefa.net/detail/BIM-706530
Modern Language Association (MLA)
Datar, Prasanna A.& Auti, Pratibha B.. Design and synthesis of novel 4-substituted 1, 4-dihydropyridine derivatives as hypotensive agent. Journal of Saudi Chemical Society Vol. 20, no. 5 (Sep. 2016), pp.510-516.
https://search.emarefa.net/detail/BIM-706530
American Medical Association (AMA)
Datar, Prasanna A.& Auti, Pratibha B.. Design and synthesis of novel 4-substituted 1, 4-dihydropyridine derivatives as hypotensive agent. Journal of Saudi Chemical Society. 2016. Vol. 20, no. 5, pp.510-516.
https://search.emarefa.net/detail/BIM-706530
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 515-516
Record ID
BIM-706530