[Bmim] BF4 ionic liquid : an efficient reaction medium for the one-pot multi-component synthesis of 2-amino-4, 6-diphenylpyridine-3-carbonitrile derivatives

Abstract EN

-One-pot condensation from aromatic aldehyde, methyl ketone, malononitrile and ammonium acetate in the presence of the ionic liquid (IL), 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim][BF4]), affords the corresponding 2-amino-4,6-diphenylpyridine-3-carbonitrile derivatives.

This method has the advantage of short routine, high yields and being environmentally- friendly.

Here, the need for catalyst is avoided through the use of catalytically active ionic liquid as solvent.

Furthermore, the possible mechanism is also proposed.